Is there a role for IGF1R and c-MET pathways in resistance to cetuximab in metastatic colorectal cancer?

Alessandro Inno; Mariantonietta Di Salvatore; Tonia Cenci; Maurizio Martini; Armando Orlandi; Antonia Strippoli; Anna Maria Ferrara; Cinzia Bagala'; Alessandra Cassano; Luigi Maria Larocca; Carlo Antonio Barone

doi:10.1016/j.clcc.2011.03.028

Is there a role for IGF1R and c-MET pathways in resistance to cetuximab in metastatic colorectal cancer?

Alessandro Inno, Mariantonietta Di Salvatore, Tonia Cenci, Maurizio Martini, Armando Orlandi, Antonia Strippoli, Anna Maria Ferrara, Cinzia Bagala', Alessandra Cassano, Luigi Maria Larocca, Carlo Antonio Barone

Risultato della ricerca: Contributo in rivista › Articolo in rivista

65 Citazioni (Scopus)

Abstract

The KRAS mutation is not responsible for all cases of resistance to anti-epidermal growth factor receptors (EGFRs) in metastatic colorectal cancer (mCRC), and new predictive and prognostic factors are actively being sought.

Lingua originale	English
pagine (da-a)	325-332
Numero di pagine	8
Rivista	Clinical Colorectal Cancer
Volume	10
DOI	https://doi.org/10.1016/j.clcc.2011.03.028
Stato di pubblicazione	Pubblicato - 2011

Keywords

Adult
Aged
Aged, 80 and over
Antibodies, Monoclonal
Antineoplastic Agents
Colorectal Neoplasms
DNA, Neoplasm
Drug Resistance, Neoplasm
Female
Gene Expression Regulation, Neoplastic
Humans
Immunoenzyme Techniques
Male
Middle Aged
Mutation
Neoplasm Metastasis
PTEN Phosphohydrolase
Polymerase Chain Reaction
Prognosis
Proto-Oncogene Proteins
Proto-Oncogene Proteins B-raf
Proto-Oncogene Proteins c-met
Receptor, Epidermal Growth Factor
Receptor, IGF Type 1
Retrospective Studies
Survival Rate
Tumor Markers, Biological
ras Proteins

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Accesso al documento

10.1016/j.clcc.2011.03.028

Altri file e collegamenti

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Cita questo

@article{333c6ed724a64767a9fd1d6049518062,

title = "Is there a role for IGF1R and c-MET pathways in resistance to cetuximab in metastatic colorectal cancer?",

abstract = "The KRAS mutation is not responsible for all cases of resistance to anti-epidermal growth factor receptors (EGFRs) in metastatic colorectal cancer (mCRC), and new predictive and prognostic factors are actively being sought.",

keywords = "Adult, Aged, Aged, 80 and over, Antibodies, Monoclonal, Antineoplastic Agents, Colorectal Neoplasms, DNA, Neoplasm, Drug Resistance, Neoplasm, Female, Gene Expression Regulation, Neoplastic, Humans, Immunoenzyme Techniques, Male, Middle Aged, Mutation, Neoplasm Metastasis, PTEN Phosphohydrolase, Polymerase Chain Reaction, Prognosis, Proto-Oncogene Proteins, Proto-Oncogene Proteins B-raf, Proto-Oncogene Proteins c-met, Receptor, Epidermal Growth Factor, Receptor, IGF Type 1, Retrospective Studies, Survival Rate, Tumor Markers, Biological, ras Proteins, Adult, Aged, Aged, 80 and over, Antibodies, Monoclonal, Antineoplastic Agents, Colorectal Neoplasms, DNA, Neoplasm, Drug Resistance, Neoplasm, Female, Gene Expression Regulation, Neoplastic, Humans, Immunoenzyme Techniques, Male, Middle Aged, Mutation, Neoplasm Metastasis, PTEN Phosphohydrolase, Polymerase Chain Reaction, Prognosis, Proto-Oncogene Proteins, Proto-Oncogene Proteins B-raf, Proto-Oncogene Proteins c-met, Receptor, Epidermal Growth Factor, Receptor, IGF Type 1, Retrospective Studies, Survival Rate, Tumor Markers, Biological, ras Proteins",

author = "Alessandro Inno and {Di Salvatore}, Mariantonietta and Tonia Cenci and Maurizio Martini and Armando Orlandi and Antonia Strippoli and Ferrara, {Anna Maria} and Cinzia Bagala' and Alessandra Cassano and Larocca, {Luigi Maria} and Barone, {Carlo Antonio}",

year = "2011",

doi = "10.1016/j.clcc.2011.03.028",

language = "English",

volume = "10",

pages = "325--332",

journal = "Clinical Colorectal Cancer",