TY - JOUR
T1 - Is there a crossroad between infections, genetics, and Henoch-Schönlein purpura?
AU - Rigante, Donato
AU - Castellazzi, Luca
AU - Bosco, Annalisa
AU - Esposito, Susanna
PY - 2013
Y1 - 2013
N2 - Henoch-Schönlein purpura is the most common systemic vasculitis in childhood, characterized by the presence of immunoglobulin A deposits in the small vessels of skin, gastrointestinal tube, joints and kidneys. Although there have been great efforts made in elucidating its pathogenic mechanisms, Henoch-Schönlein purpura etiology remains unknown: the basic scene comes across an abnormal inflammatory process deriving from immune reactions to various antigenic stimuli, which might be bacterial, viral, or parasitic agents, in a genetically prone individual. Then, a peculiar immune complex deposition in the vascular walls and overproduction of different proinflammatory molecules elicit different clinical signs, which might be differentiated according to either a specific trigger or a specific genetic make-up. The aim of this review is to make a critical appraisal of the last 15years' medical literature concerning the relationship between infections, genetics, and Henoch-Schönlein purpura in pediatrics.
AB - Henoch-Schönlein purpura is the most common systemic vasculitis in childhood, characterized by the presence of immunoglobulin A deposits in the small vessels of skin, gastrointestinal tube, joints and kidneys. Although there have been great efforts made in elucidating its pathogenic mechanisms, Henoch-Schönlein purpura etiology remains unknown: the basic scene comes across an abnormal inflammatory process deriving from immune reactions to various antigenic stimuli, which might be bacterial, viral, or parasitic agents, in a genetically prone individual. Then, a peculiar immune complex deposition in the vascular walls and overproduction of different proinflammatory molecules elicit different clinical signs, which might be differentiated according to either a specific trigger or a specific genetic make-up. The aim of this review is to make a critical appraisal of the last 15years' medical literature concerning the relationship between infections, genetics, and Henoch-Schönlein purpura in pediatrics.
KW - Henoch-Schönlein purpura
KW - Henoch-Schönlein purpura
UR - http://hdl.handle.net/10807/50683
U2 - 10.1016/j.autrev.2013.04.003
DO - 10.1016/j.autrev.2013.04.003
M3 - Article
SN - 1568-9972
VL - 12
SP - 1016
EP - 1021
JO - Autoimmunity Reviews
JF - Autoimmunity Reviews
ER -