Is serum Troponin T a useful marker of myocardial damage in newborn infants with perinatal asphyxia?

Gabriella De Rosa, Enrico Zecca, Simonetta Costa, Daniele De Luca, Manuela Pardeo, Costantino Romagnoli, Giada Barbato

Risultato della ricerca: Contributo in rivistaArticolo in rivista

66 Citazioni (Scopus)

Abstract

AIM: To assess the correlation of echocardiographic signs of myocardial damage to serum cardiac troponin T (cTnT) concentrations in newborn infants with perinatal asphyxia. METHODS: Electocardiograms (ECG) and echocardiograms (Echo) were obtained during the first 24 h of life from 29 asphyxiated and 30 control infants and correlated with cTnT concentrations. The echocardiographic parameters included systolic ventricular performance, preload, afterload, diastolic function, stroke volume (SV), left ventricular output (LVO), hyperechogenity of the papillary muscles and insufficiency of the atrioventricular valves. RESULTS: LVO and SV were lower but CTnT were significantly higher in asphyxiated than in control infants: 0.15 (010-0.23) vs. 0.05 (0.02-0.13), p < 0.001). Asphyxiated infants with signs of myocardial damage were associated with significantly higher cTnT than those without, 0.20 (0.11-0.28) and 0.11 (0.05-0.14 ug/L), p = 0.04. CONCLUSION: Cardiac troponin may prove to be valuable in evaluating myocardial damage in birth asphyxia. However, the degree of prematurity may complicate the assessment.
Lingua originaleEnglish
pagine (da-a)181-184
Numero di pagine4
RivistaACTA PAEDIATRICA
Stato di pubblicazionePubblicato - 2007

Keywords

  • cardiac troponin T
  • echocardiography
  • myocardial ischaemia
  • perinatal asphyxia

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