Is ACPA positivity the main driver for rheumatoid arthritis treatment? Pros and cons

Stefano Alivernini, Mauro Galeazzi, Hagit Peleg, Barbara Tolusso, Elisa Gremese, Gianfranco Ferraccioli, Yaakov Naparstek

Risultato della ricerca: Contributo in rivistaArticolo in rivista

11 Citazioni (Scopus)


Rheumatoid Arthritis (RA) is an autoimmune chronic disease that is characterized by the positivity of various antibodies, the most specific being autoantibodies against citrullinated antigens (ACPA). Despite ACPA are not arthritogenic by themselves, ACPA positive individuals have high risk of RA development and ACPA positivity is associated with severe erosive phenotype and higher mortality rate compared to seronegative RA. Moreover, ACPA status is associated with favorable response to biologics targeting pathways involving autoantibody producing cells as B lymphocytes. In the current review we have discussed the pros and cons on the available scientific evidences, regarding the diagnostic, prognostic and management implications of ACPAs in RA.
Lingua originaleEnglish
pagine (da-a)1096-1102
Numero di pagine7
RivistaAutoimmunity Reviews
Stato di pubblicazionePubblicato - 2017


  • Anti-citrullinated peptide antibodies
  • Arthritis, Rheumatoid
  • Autoantibodies
  • Biomarker
  • Biomarkers
  • Humans
  • Immunology
  • Immunology and Allergy
  • Peptides, Cyclic
  • Prognosis
  • Rheumatoid arthritis


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