Involvement of Fas/FasL system in the pathogenesis of autoimmune diseases and Wilson's disease

Ruggero De Maria Marchiano, Giorgio Stassi, Valentina Di Felice, Matilde Todaro, Francesco Cappello, Giovanni Zummo, Felicia Farina, Massimo Trucco

Risultato della ricerca: Contributo in rivistaArticolo in rivista

10 Citazioni (Scopus)

Abstract

The interaction of Fas with FasL has been demonstrated to be implicated in the pathogenesis of several autoimmune and liver diseases. Recently, attention has been focused on the hypothesis that thyrocytes and β cells undergo massive Fas/FasL-mediated apoptosis during autoimmune response. Similarly, hepatocyte cell death occurring following copper accumulation points towards the same mechanism.
Lingua originaleEnglish
pagine (da-a)129-133
Numero di pagine5
RivistaArchivum Immunologiae et Therapiae Experimentalis
Volume47
Stato di pubblicazionePubblicato - 1999

Keywords

  • Apoptosis
  • Autoimmune diseases
  • Fas
  • Hashimoto's thyroiditis
  • Immunology
  • Insulin-dependent diabetes mellitus
  • Wilson's disease

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