Investigating the role of DNA damage in tobacco smoking-induced spine degeneration

Luigi Aurelio Nasto; Kevin Ngo; Adriana S. Leme; Andria R. Robinson; Qing Dong; Peter Roughley; Arvydas Usas; Gwendolyn A. Sowa; Enrico Pola; James Kang; Laura J. Niedernhofer; Steven Shapiro; Nam V. Vo

doi:10.1016/j.spinee.2013.08.034

Investigating the role of DNA damage in tobacco smoking-induced spine degeneration

Luigi Aurelio Nasto, Kevin Ngo, Adriana S. Leme, Andria R. Robinson, Qing Dong, Peter Roughley, Arvydas Usas, Gwendolyn A. Sowa, Enrico Pola, James Kang, Laura J. Niedernhofer, Steven Shapiro, Nam V. Vo

Università Cattolica del Sacro Cuore

Risultato della ricerca: Contributo in rivista › Articolo

30 Citazioni (Scopus)

Abstract

Tobacco smoking is a key risk factor for spine degeneration. However, the underlying mechanism by which smoking induces degeneration is not known. Recent studies implicate DNA damage as a cause of spine and intervertebral disc degeneration. Because tobacco smoke contains many genotoxins, we hypothesized that tobacco smoking promotes spine degeneration by inducing cellular DNA damage.

Lingua originale	Inglese
pagine (da-a)	1529-1532
Numero di pagine	4
Rivista	THE SPINE JOURNAL
DOI	https://doi.org/10.1016/j.spinee.2013.08.034
Stato di pubblicazione	Pubblicato - 2013

Keywords

Aggrecan
DNA damage repair
Intervertebral disc degeneration
Matrix metalloproteinases
Matrix proteoglycans
Tobacco smoking

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10.1016/j.spinee.2013.08.034

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title = "Investigating the role of DNA damage in tobacco smoking-induced spine degeneration",

abstract = "Tobacco smoking is a key risk factor for spine degeneration. However, the underlying mechanism by which smoking induces degeneration is not known. Recent studies implicate DNA damage as a cause of spine and intervertebral disc degeneration. Because tobacco smoke contains many genotoxins, we hypothesized that tobacco smoking promotes spine degeneration by inducing cellular DNA damage.",

keywords = "Aggrecan, DNA damage repair, Intervertebral disc degeneration, Matrix metalloproteinases, Matrix proteoglycans, Tobacco smoking, Aggrecan, DNA damage repair, Intervertebral disc degeneration, Matrix metalloproteinases, Matrix proteoglycans, Tobacco smoking",

author = "Nasto, \{Luigi Aurelio\} and Kevin Ngo and Leme, \{Adriana S.\} and Robinson, \{Andria R.\} and Qing Dong and Peter Roughley and Arvydas Usas and Sowa, \{Gwendolyn A.\} and Enrico Pola and James Kang and Niedernhofer, \{Laura J.\} and Steven Shapiro and Vo, \{Nam V.\}",

year = "2013",

doi = "10.1016/j.spinee.2013.08.034",

language = "English",

pages = "1529--1532",

journal = "THE SPINE JOURNAL",

issn = "1529-9430",

publisher = "New York, NY : Elsevier Science Inc., c2001-",

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TY - JOUR

T1 - Investigating the role of DNA damage in tobacco smoking-induced spine degeneration

AU - Nasto, Luigi Aurelio

AU - Ngo, Kevin

AU - Leme, Adriana S.

AU - Robinson, Andria R.

AU - Dong, Qing

AU - Roughley, Peter

AU - Usas, Arvydas

AU - Sowa, Gwendolyn A.

AU - Pola, Enrico

AU - Kang, James

AU - Niedernhofer, Laura J.

AU - Shapiro, Steven

AU - Vo, Nam V.

PY - 2013

Y1 - 2013

N2 - Tobacco smoking is a key risk factor for spine degeneration. However, the underlying mechanism by which smoking induces degeneration is not known. Recent studies implicate DNA damage as a cause of spine and intervertebral disc degeneration. Because tobacco smoke contains many genotoxins, we hypothesized that tobacco smoking promotes spine degeneration by inducing cellular DNA damage.

AB - Tobacco smoking is a key risk factor for spine degeneration. However, the underlying mechanism by which smoking induces degeneration is not known. Recent studies implicate DNA damage as a cause of spine and intervertebral disc degeneration. Because tobacco smoke contains many genotoxins, we hypothesized that tobacco smoking promotes spine degeneration by inducing cellular DNA damage.

KW - Aggrecan

KW - DNA damage repair

KW - Intervertebral disc degeneration

KW - Matrix metalloproteinases

KW - Matrix proteoglycans

KW - Tobacco smoking

KW - Aggrecan

KW - DNA damage repair

KW - Intervertebral disc degeneration

KW - Matrix metalloproteinases

KW - Matrix proteoglycans

KW - Tobacco smoking

UR - http://hdl.handle.net/10807/51970

U2 - 10.1016/j.spinee.2013.08.034

DO - 10.1016/j.spinee.2013.08.034

M3 - Article

SN - 1529-9430

SP - 1529

EP - 1532

JO - THE SPINE JOURNAL

JF - THE SPINE JOURNAL

ER -

Investigating the role of DNA damage in tobacco smoking-induced spine degeneration

Abstract

Keywords

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