Investigating the role of DNA damage in tobacco smoking-induced spine degeneration

Luigi Aurelio Nasto, Kevin Ngo, Adriana S. Leme, Andria R. Robinson, Qing Dong, Peter Roughley, Arvydas Usas, Gwendolyn A. Sowa, Enrico Pola, James Kang, Laura J. Niedernhofer, Steven Shapiro, Nam V. Vo

Risultato della ricerca: Contributo in rivistaArticolo in rivista

30 Citazioni (Scopus)


Tobacco smoking is a key risk factor for spine degeneration. However, the underlying mechanism by which smoking induces degeneration is not known. Recent studies implicate DNA damage as a cause of spine and intervertebral disc degeneration. Because tobacco smoke contains many genotoxins, we hypothesized that tobacco smoking promotes spine degeneration by inducing cellular DNA damage.
Lingua originaleEnglish
pagine (da-a)1529-1532
Numero di pagine4
Stato di pubblicazionePubblicato - 2013


  • Aggrecan
  • DNA damage repair
  • Intervertebral disc degeneration
  • Matrix metalloproteinases
  • Matrix proteoglycans
  • Tobacco smoking


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