Investigating the role of DNA damage in tobacco smoking-induced spine degeneration

Luigi Aurelio Nasto, Enrico Pola, Kevin Ngo, Adriana S. Leme, Andria R. Robinson, Qing Dong, Peter Roughley, Arvydas Usas, Gwendolyn A. Sowa, James Kang, Laura J. Niedernhofer, Steven Shapiro, Nam V. Vo

Risultato della ricerca: Contributo in rivistaArticolo in rivista

29 Citazioni (Scopus)

Abstract

Tobacco smoking is a key risk factor for spine degeneration. However, the underlying mechanism by which smoking induces degeneration is not known. Recent studies implicate DNA damage as a cause of spine and intervertebral disc degeneration. Because tobacco smoke contains many genotoxins, we hypothesized that tobacco smoking promotes spine degeneration by inducing cellular DNA damage.
Lingua originaleEnglish
pagine (da-a)1529-1532
Numero di pagine4
RivistaTHE SPINE JOURNAL
DOI
Stato di pubblicazionePubblicato - 2013

Keywords

  • Aggrecan
  • DNA damage repair
  • Intervertebral disc degeneration
  • Matrix metalloproteinases
  • Matrix proteoglycans
  • Tobacco smoking

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