Invasive growth: A two-way street for semaphorin signalling

Polo M. Comoglio; Luca Tamagnone; Silvia Giordano

doi:10.1038/ncb1204-1155

Invasive growth: A two-way street for semaphorin signalling

Polo M. Comoglio, Luca Tamagnone, Silvia Giordano

University of Turin

Risultato della ricerca: Contributo in rivista › Articolo in rivista

18 Citazioni (Scopus)

Abstract

Growing evidence suggests that semaphorins - known to provide directional cues during axon guidance - also provide regulatory signals for cell migration during tissue morphogenesis. During heart development, it is crucial that semaphorins can signal bidirectionally, functioning as both a ligand and a receptor. Through these distinct signalling pathways, semaphorins can provide both 'stop' and 'go' signals for cell motility and invasive growth.

Lingua originale	English
pagine (da-a)	1155-1157
Numero di pagine	3
Rivista	Nature Cell Biology
Volume	6
DOI	https://doi.org/10.1038/ncb1204-1155
Stato di pubblicazione	Pubblicato - 2004

Keywords

SEMAPHORINS

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10.1038/ncb1204-1155

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title = "Invasive growth: A two-way street for semaphorin signalling",

abstract = "Growing evidence suggests that semaphorins - known to provide directional cues during axon guidance - also provide regulatory signals for cell migration during tissue morphogenesis. During heart development, it is crucial that semaphorins can signal bidirectionally, functioning as both a ligand and a receptor. Through these distinct signalling pathways, semaphorins can provide both 'stop' and 'go' signals for cell motility and invasive growth.",

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AU - Comoglio, Polo M.

AU - Tamagnone, Luca

AU - Giordano, Silvia

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N2 - Growing evidence suggests that semaphorins - known to provide directional cues during axon guidance - also provide regulatory signals for cell migration during tissue morphogenesis. During heart development, it is crucial that semaphorins can signal bidirectionally, functioning as both a ligand and a receptor. Through these distinct signalling pathways, semaphorins can provide both 'stop' and 'go' signals for cell motility and invasive growth.

AB - Growing evidence suggests that semaphorins - known to provide directional cues during axon guidance - also provide regulatory signals for cell migration during tissue morphogenesis. During heart development, it is crucial that semaphorins can signal bidirectionally, functioning as both a ligand and a receptor. Through these distinct signalling pathways, semaphorins can provide both 'stop' and 'go' signals for cell motility and invasive growth.

KW - SEMAPHORINS

UR - http://hdl.handle.net/10807/141388

U2 - 10.1038/ncb1204-1155

DO - 10.1038/ncb1204-1155

M3 - Article

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VL - 6

SP - 1155

EP - 1157

JO - Nature Cell Biology

JF - Nature Cell Biology

ER -

Invasive growth: A two-way street for semaphorin signalling

Abstract

Keywords

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