INTRATHECALLY ADMINISTERED M-AMSA IN THE RHESUS-MONKEY

Riccardo Riccardi, Paul Gormley, Dondra O'Neill, David Poplack

Risultato della ricerca: Contributo in rivistaArticolo in rivista

Abstract

4'-(9-Acridinylamino)-methanesulfon-m-anisidide (m-AMSA) is an acridine compound that has been found useful in the systemic treatment of acute leukemia. This paper specifically investigates the CSF pharmacokinetics of m-AMSA following both intravenous and intraventricular administration in a subhuman primate model. Following intravenous administration, m-AMSA crossed the blood-brain barrier poorly; cerebrospinal fluid (CSF) concentrations were only 1-3% of systemic concentrations. Intraventricular administration of drug achieved high initial ventricular fluid concentrations, but the drug was rapidly cleared with a half-life of 115 min. Following 500 micrograms of intraventricular drug, CSF concentrations of m-AMSA remained above 1 microM for only 6 h. These data suggest that m-AMSA has potential as an intrathecal agent against meningeal leukemia refractory to more conventional therapy, but detailed toxicology and neurohistopathology will be required before intra-CSF m-AMSA can be considered for human use.
Lingua originaleEnglish
pagine (da-a)101-107
Numero di pagine7
RivistaCancer Drug Delivery
Volume1
DOI
Stato di pubblicazionePubblicato - 1984

Keywords

  • INTRATHECALLY
  • M-AMSA
  • RHESUS-MONKEYS

Fingerprint Entra nei temi di ricerca di 'INTRATHECALLY ADMINISTERED M-AMSA IN THE RHESUS-MONKEY'. Insieme formano una fingerprint unica.

Cita questo