Intranasal therapy with opioids for children and adolescents with cancer: results from clinical studies

Stefano Mastrangelo, Palma Maurizi, Antonio Ruggiero, Michele Antonio Capozza, Giorgio Attina'

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

1 Citazioni (Scopus)

Abstract

Opioids are essential for the treatment of pain, which is a serious symptom for children and adolescents affected by cancer. Intranasal opioids may be very useful for the treatment of breakthrough pain in children and adolescents with cancer, for their little invasiveness, ease of administration, rapid onset of action, and high bioavailability. Intranasal drug delivery may be influenced by anatomical and physiological factors (nasal mucosa absorption area, mucociliary clearance, enzymatic activity, anatomical anomalies, chronic or inflammatory alterations of nasal mucosa), drug-related factors (molecular weight, solubility), and delivery device. Fentanyl is a lipophilic opioid commonly proposed for intranasal use among pediatric patients, but no studies have been conducted yet about intranasal use of other available opioids for management of pediatric cancer pain. In this review, we analyze several elements which may influence absorption of intranasal opioids in children and adolescents, with a focus on pharmacokinetics and therapeutic aspects of each opioid currently available for intranasal use.
Lingua originaleEnglish
pagine (da-a)3639-3645
Numero di pagine7
RivistaSupportive Care in Cancer
Volume27
DOI
Stato di pubblicazionePubblicato - 2019

Keywords

  • Administration, Intranasal
  • Adolescent
  • Analgesics, Opioid
  • Breakthrough Pain
  • Cancer Pain
  • Cancer pain
  • Child
  • Drug Delivery Systems
  • Fentanyl
  • Humans
  • Intranasal
  • Nasal Mucosa
  • Neoplasms
  • Opioids
  • Pain Measurement
  • Pediatric patients

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