Intranasal dexmedetomidine, although still off-label, recently boasted an increasing consensus for different uses, namely, in diagnostic non-painful procedures, in painful procedures and in surgical premedication. However, at present, there is no consensus regarding indications, dosage and timing for administration. This article aims to provide a comprehensive literature analysis and summarize the more recent evidence of research on pediatric intranasal dexmedetomidine, in the effort to better delineate usefulness and limits for each specific indication. In summary, available pediatric evidence confirms efficacy and safety of dexmedetomidine for intranasal administration. Pharmacological profile for the various pediatric ages and procedures still needs quality studies and pharmacokinetic in-depth analysis.
Lingua originaleEnglish
pagine (da-a)1334-1345
Numero di pagine12
RivistaMinerva Anestesiologica
Stato di pubblicazionePubblicato - 2019


  • Deep sedation
  • Dexmedetomidine
  • Intranasal administration
  • Pediatrics
  • Premedication


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