Intraluminal Brachytherapy in Unresectable Extrahepatic Biliary Duct Cancer: An Italian Pooled Analysis

Rosa Autorino, Silvia Bisiello, Brigida Pappalardi, Vanessa Privitera, Milly Buwenge, Federica Piccolo, Carlotta Masciocchi, Luca Tagliaferri, Gabriella Macchia, Clelia Delle Curti, Marco Luppatteli, Annamaria Cerrotta, Alessio Giuseppe Morganti, Alessio Giuseppe Morganti, Vincenzo Valentini, Giancarlo Mattiucci

Risultato della ricerca: Contributo in rivistaArticolo in rivista


Background/Aim: To evaluate the outcome of patients with unresectable extrahepatic cholangiocarcinoma (CC) treated with external-beam radiotherapy (EBRT) and concurrent chemotherapy (CT) with or without intraluminal brachytherapy (ILBT) boost or with definitive ILBT. Patients and Methods: A pooled analysis of patients with nonmetastatic unresectable CC was performed. They were treated in three different institution with EBRT plus CT with or without an ILBT boost. Some patients received only ILBT with curative dose. Results: Seventy-three patients were included in the analysis. Thirty-nine patients (53%) received EBRT treatment with ILBT boost (18 patients with CT during EBRT), while 28 patients (38%) were treated with EBRT (CT in 26 patients) and 6 patients (8.2%) with definitive ILBT (2 patients with CT). CT was administered including either the use of gemcitabine or 5-fluorouracil. With a median followup of 16 month (range=1-94 months), median overall survival (OS) was 16 months. Overall median LC was 16 months and patients who underwent ILBT had a better local control (LC) (p=0.018). Conclusion: The role of ILBT in unresectable CC is not yet supported by robust evidence in the literature. However, within this limit, preliminary results seem to suggest an improved local control in patients treated with ILBT, almost comparable to the ones of standard chemo-radiotherapy (CRT).
Lingua originaleEnglish
pagine (da-a)3417-3421
Numero di pagine5
RivistaAnticancer Research
Stato di pubblicazionePubblicato - 2020


  • Adult
  • Aged
  • Aged, 80 and over
  • Bile Duct Neoplasms
  • Bile Ducts, Extrahepatic
  • Brachytherapy
  • Cholangiocarcinoma
  • Female
  • Humans
  • Italy
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Neoplasm Staging
  • Radiotherapy
  • Radiotherapy Dosage
  • Retrospective Studies
  • Tomography, X-Ray Computed
  • Treatment Outcome
  • biliary tract cancers
  • brachytherapy
  • chemoradiation
  • cholangiocarcinoma


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