TY - JOUR
T1 - Intestinal microbiota in adult patients with Short Bowel Syndrome: Preliminary results from a pilot study
AU - Boccia, Stefania
AU - Torre, Ida
AU - Santarpia, Lidia
AU - Iervolino, Carmela
AU - Del Piano, Concetta
AU - Puggina, Anna
AU - Pastorino, Roberta
AU - Dragic, Miroslav
AU - Amore, Rosarita
AU - Borriello, Tonia
AU - Palladino, Raffaele
AU - Pennino, Francesca
AU - Contaldo, Franco
AU - Pasanisi, Fabrizio
PY - 2017
Y1 - 2017
N2 - Introduction: Intestinal bacterial flora plays a central role in human intestinal health and disease. Short Bowel Syndrome (SBS), a clinical condition deriving from extensive bowel resections, influence intestinal microbiota (IM) composition in order to reach a new metabolic balance. Little is known about IM in adult patients after wide intestinal resections. Material and methods: Fecal samples from 12 SBS patients and 16 controls were analyzed in their microbial profile by using both culture-dependent method and quantitative Real-Time PCR (qRT-PCR). Results: The two methods revealed significant lower concentrations of . Bacteroidetes (p-value = .02), . Firmicutes (p-value = .05), . Bifidobacterium (p-value < .01), and . Methanobrevibacter Smithii (p-value = .04) in SBS patients than controls. Conclusions: The significantly different fecal microbiome in SBS patients compared with healthy controls could open new perspectives on the care of their intestinal functions.
AB - Introduction: Intestinal bacterial flora plays a central role in human intestinal health and disease. Short Bowel Syndrome (SBS), a clinical condition deriving from extensive bowel resections, influence intestinal microbiota (IM) composition in order to reach a new metabolic balance. Little is known about IM in adult patients after wide intestinal resections. Material and methods: Fecal samples from 12 SBS patients and 16 controls were analyzed in their microbial profile by using both culture-dependent method and quantitative Real-Time PCR (qRT-PCR). Results: The two methods revealed significant lower concentrations of . Bacteroidetes (p-value = .02), . Firmicutes (p-value = .05), . Bifidobacterium (p-value < .01), and . Methanobrevibacter Smithii (p-value = .04) in SBS patients than controls. Conclusions: The significantly different fecal microbiome in SBS patients compared with healthy controls could open new perspectives on the care of their intestinal functions.
KW - Critical Care and Intensive Care Medicine
KW - Intestinal microbiota
KW - Nutrition and Dietetics
KW - Short Bowel Syndrome
KW - Critical Care and Intensive Care Medicine
KW - Intestinal microbiota
KW - Nutrition and Dietetics
KW - Short Bowel Syndrome
UR - http://hdl.handle.net/10807/92929
UR - http://www.elsevier-international.com/journals/clnu/
U2 - 10.1016/j.clnu.2016.09.028
DO - 10.1016/j.clnu.2016.09.028
M3 - Article
SN - 0261-5614
SP - 1707
EP - 1709
JO - Clinical Nutrition
JF - Clinical Nutrition
ER -
