Interrelationship between IL-3 and mast cells

Giuliano Giorgio Cerulli, Franco Pandolfi, S. K. Kritas, A. Saggini, G. Cerulli, A. Caraffa, P. Antinolfi, A. Pantalone, R. Saggini, S. Frydas, M. Rosati, M. Tei, A. Speziali, P. Conti

Risultato della ricerca: Contributo in rivistaArticolo in rivista

12 Citazioni (Scopus)

Abstract

It is well established that mast cells, which are found in the tissues in the proximity of small blood vessels and post-capillary venules, play a key role in the early phase of IgE-mediated allergic reactions. A greatly expanded understanding of the biology of IL-3 has emerged since the early 1980s. IL-3 is a specific factor that stimulates the growth of hematopoietic stem and progenitor cells of a variety of lineages and can promote the proliferation of certain classes of lymphocytes distinct from those that are dependent on IL-2. IL-3 has been identified among the most important cytokines for regulation of mast cell growth and differentiation, migration and effector function activities of many hematopoietic cells. IL-3 termed multi colony-stimulating-factor (multi-CSF) or mast cell growth factor (MCGF) is a haematopoietic growth factor which stimulates the formation of colonies for erythroid, megakaryocytic, granulocytic and monocytic lineages. It is predominantly produced by activated T cells, natural killer (NK) cells and mast cells and supports the growth-promoting effects of SCF on mast cell precursors. IL-3 causes severe hypersensivity reactions and plays a pivotal role in exacerbating the inflammatory response in vivo. Here we report the interrelationship between IL-3 and mast cells.
Lingua originaleEnglish
pagine (da-a)17-21
Numero di pagine5
RivistaJOURNAL OF BIOLOGICAL REGULATORS & HOMEOSTATIC AGENTS
Volume28
Stato di pubblicazionePubblicato - 2014

Keywords

  • Animals
  • Calcium
  • Extracellular Signal-Regulated MAP Kinases
  • Humans
  • Inflammation
  • Interleukin-3
  • Mast Cells

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