International experts panel meeting of the Italian association of thoracic oncology on antiangiogenetic drugs for non-small cell lung cancer: Realities and hopes

Emilio Bria, Filippo De Marinis, Fortunato Ciardiello, Lucio Crinò, Jean Yves Douillard, Frank Griesinger, Diether Lambrechts, Maurice Perol, Suresh S. Ramalingam, Egbert F. Smit, Cesare Gridelli

Risultato della ricerca: Contributo in rivistaArticolo in rivista

7 Citazioni (Scopus)

Abstract

Angiogenesis, one of the hallmarks of cancer, occurs when new blood vessels feed malignant cells, providing oxygen and nutrients, promoting tumor growth, and allowing tumor cells to escape into the circulation, thus leading to metastases. To date, a series of antiangiogenic drugs (either monoclonal antibodies or small molecules) have been approved by regulatory agencies for the treatment of advanced non-small cell lung cancer, and they are currently available for both first- and second-line therapy. The overall benefit of these drugs seems modest (although clearly significant), especially when administered as a single agent, and there is no clear consensus with regard to which patients should be candidates to receive these drugs across the different disease settings. From the biological perspective, angiogenesis represents a difficult and complex process to explore, given the interference with other key pathways and the dynamic evolution during the disease's history. Indeed, this process is complicated by the presence of multiple targets to hit, polymorphisms, hypoxiadependent modifications, and epigenetics. These difficulties do not allow capture of which specific key pathways can be identified as biomarkers of efficacy so as to maximize to overall benefit of such drugs. An International Experts Panel Meeting was inspired by the absence of clear recommendations to address which patients should receive antiangiogenic drugs in the context of advanced non-small cell lung cancer so as to support decisions for clinical practice on a daily basis and determine priorities for future research. After a literature review and panelists consensus, a series of recommendations were defined to support decisions for the daily clinical practice and to indicate a potential road map for translational research.
Lingua originaleEnglish
pagine (da-a)1153-1169
Numero di pagine17
RivistaJournal of Thoracic Oncology
Volume11
DOI
Stato di pubblicazionePubblicato - 2016

Keywords

  • Angiogenesis
  • Angiogenesis Inhibitors
  • Antibodies, Monoclonal
  • Bevacizumab
  • Biomarkers
  • Carcinoma, Non-Small-Cell Lung
  • Clinical Trials as Topic
  • Humans
  • Indoles
  • Lung Neoplasms
  • Lung cancer
  • NSCLC
  • Neovascularization, Pathologic
  • Oncology
  • Patient Selection
  • Pulmonary and Respiratory Medicine
  • Review
  • Vascular Endothelial Growth Factor A

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