International consensus statement on the diagnosis and management of phaeochromocytoma and paraganglioma in children and adolescents

Ruth T Casey; Emile Hendriks; Cheri Deal; Steven G Waguespack; Verena Wiegering; Antje Redlich; Scott Akker; Rathi Prasad; Martin Fassnacht; Roderick Clifton-Bligh; Laurence Amar; Stefan Bornstein; Letizia Canu; Evangelia Charmandari; Alexandra Chrisoulidou; Maria Currás Freixes; Ronald de Krijger; Luisa de Sanctis; Antonio Fojo; Amol J Ghia; Angela Huebner; Vasilis Kosmoliaptsis; Michaela Kuhlen; Marco Raffaelli; Charlotte Lussey-Lepoutre; Stephen D Marks; Naris Nilubol; Mirko Parasiliti-Caprino; Henri H J L M Timmers; Anna Lena Zietlow; Mercedes Robledo; Anne-Paule Gimenez-Roqueplo; Ashley B Grossman; David Taïeb; Eamonn R Maher; Jacques W M Lenders; Graeme Eisenhofer; Camilo Jimenez; Karel Pacak; Christina Pamporaki

doi:10.1038/s41574-024-01024-5

International consensus statement on the diagnosis and management of phaeochromocytoma and paraganglioma in children and adolescents

Ruth T Casey^*
, Emile Hendriks
, Cheri Deal
, Steven G Waguespack
, Verena Wiegering
, Antje Redlich
, Scott Akker
, Rathi Prasad
, Martin Fassnacht
, Roderick Clifton-Bligh
, Laurence Amar
, Stefan Bornstein
, Letizia Canu
, Evangelia Charmandari
, Alexandra Chrisoulidou
, Maria Currás Freixes
, Ronald de Krijger
, Luisa de Sanctis
, Antonio Fojo
, Amol J Ghia

Angela Huebner, Vasilis Kosmoliaptsis, Michaela Kuhlen, Marco Raffaelli, Charlotte Lussey-Lepoutre, Stephen D Marks, Naris Nilubol, Mirko Parasiliti-Caprino, Henri H J L M Timmers, Anna Lena Zietlow, Mercedes Robledo, Anne-Paule Gimenez-Roqueplo, Ashley B Grossman, David Taïeb, Eamonn R Maher, Jacques W M Lenders, Graeme Eisenhofer, Camilo Jimenez, Karel Pacak, Christina Pamporaki^*

^*Autore corrispondente per questo lavoro

Cambridge University Hospitals NHS Foundation Trust
University of Würzburg
Otto von Guericke University Magdeburg
St Bartholomew's Hospital
Queen Mary University of London
Royal North Shore Hospital
Assistance publique – Hôpitaux de Paris
Université de Paris
Technische Universität Dresden (TU Dresden)
Azienda Ospedaliera Careggi
University of Florence
National and Kapodistrian University of Athens
Centro de Investigación Biomédica en Red
Princess Máxima Center for Pediatric Oncology
Utrecht University
University of Turin
Columbia University
University of Cambridge
Augsburg University
Sorbonne Université
National Institutes of Health
Technische Universität Dresden
Hopital La Timone
University of Texas MD Anderson Cancer Center

Risultato della ricerca: Contributo in rivista › Abstract di Conferenza

Abstract

Phaeochromocytomas and paragangliomas (PPGL) are rare neuroendocrine tumours that arise not only in adulthood but also in childhood and adolescence. Up to 70–80% of childhood PPGL are hereditary, accounting for a higher incidence of metastatic and/or multifocal PPGL in paediatric patients than in adult patients. Key differences in the tumour biology and management, together with rare disease incidence and therapeutic challenges in paediatric compared with adult patients, mandate close expert cross-disciplinary teamwork. Teams should ideally include adult and paediatric endocrinologists, oncologists, cardiologists, surgeons, geneticists, pathologists, radiologists, clinical psychologists and nuclear medicine physicians. Provision of an international Consensus Statement should improve care and outcomes for children and adolescents with these tumours.

Lingua originale	Inglese
pagine (da-a)	729-748
Numero di pagine	20
Rivista	Nature Reviews Endocrinology
Volume	20
Numero di pubblicazione	12
DOI	https://doi.org/10.1038/s41574-024-01024-5
Stato di pubblicazione	Pubblicato - 2024

OSS delle Nazioni Unite

Questo processo contribuisce al raggiungimento dei seguenti obiettivi di sviluppo sostenibile

SDG 3 Salute e benessere

All Science Journal Classification (ASJC) codes

Endocrinologia, Diabete e Metabolismo
Endocrinologia

Keywords

phaeochromocytoma
paraganglioma in children

Accesso al documento

10.1038/s41574-024-01024-5

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Casey, R. T., Hendriks, E., Deal, C., Waguespack, S. G., Wiegering, V., Redlich, A., Akker, S., Prasad, R., Fassnacht, M., Clifton-Bligh, R., Amar, L., Bornstein, S., Canu, L., Charmandari, E., Chrisoulidou, A., Freixes, M. C., de Krijger, R., de Sanctis, L., Fojo, A., ... Pamporaki, C. (2024). International consensus statement on the diagnosis and management of phaeochromocytoma and paraganglioma in children and adolescents. Nature Reviews Endocrinology, 20(12), 729-748. https://doi.org/10.1038/s41574-024-01024-5

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abstract = "Phaeochromocytomas and paragangliomas (PPGL) are rare neuroendocrine tumours that arise not only in adulthood but also in childhood and adolescence. Up to 70{\textendash}80\% of childhood PPGL are hereditary, accounting for a higher incidence of metastatic and/or multifocal PPGL in paediatric patients than in adult patients. Key differences in the tumour biology and management, together with rare disease incidence and therapeutic challenges in paediatric compared with adult patients, mandate close expert cross-disciplinary teamwork. Teams should ideally include adult and paediatric endocrinologists, oncologists, cardiologists, surgeons, geneticists, pathologists, radiologists, clinical psychologists and nuclear medicine physicians. Provision of an international Consensus Statement should improve care and outcomes for children and adolescents with these tumours.",

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doi = "10.1038/s41574-024-01024-5",

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Casey, RT, Hendriks, E, Deal, C, Waguespack, SG, Wiegering, V, Redlich, A, Akker, S, Prasad, R, Fassnacht, M, Clifton-Bligh, R, Amar, L, Bornstein, S, Canu, L, Charmandari, E, Chrisoulidou, A, Freixes, MC, de Krijger, R, de Sanctis, L, Fojo, A, Ghia, AJ, Huebner, A, Kosmoliaptsis, V, Kuhlen, M, Raffaelli, M, Lussey-Lepoutre, C, Marks, SD, Nilubol, N, Parasiliti-Caprino, M, Timmers, HHJLM, Zietlow, AL, Robledo, M, Gimenez-Roqueplo, A-P, Grossman, AB, Taïeb, D, Maher, ER, Lenders, JWM, Eisenhofer, G, Jimenez, C, Pacak, K & Pamporaki, C 2024, 'International consensus statement on the diagnosis and management of phaeochromocytoma and paraganglioma in children and adolescents', Nature Reviews Endocrinology, vol. 20, n. 12, pagg. 729-748. https://doi.org/10.1038/s41574-024-01024-5

TY - JOUR

T1 - International consensus statement on the diagnosis and management of phaeochromocytoma and paraganglioma in children and adolescents

AU - Casey, Ruth T

AU - Hendriks, Emile

AU - Deal, Cheri

AU - Waguespack, Steven G

AU - Wiegering, Verena

AU - Redlich, Antje

AU - Akker, Scott

AU - Prasad, Rathi

AU - Fassnacht, Martin

AU - Clifton-Bligh, Roderick

AU - Amar, Laurence

AU - Bornstein, Stefan

AU - Canu, Letizia

AU - Charmandari, Evangelia

AU - Chrisoulidou, Alexandra

AU - Freixes, Maria Currás

AU - de Krijger, Ronald

AU - de Sanctis, Luisa

AU - Fojo, Antonio

AU - Ghia, Amol J

AU - Huebner, Angela

AU - Kosmoliaptsis, Vasilis

AU - Kuhlen, Michaela

AU - Raffaelli, Marco

AU - Lussey-Lepoutre, Charlotte

AU - Marks, Stephen D

AU - Nilubol, Naris

AU - Parasiliti-Caprino, Mirko

AU - Timmers, Henri H J L M

AU - Zietlow, Anna Lena

AU - Robledo, Mercedes

AU - Gimenez-Roqueplo, Anne-Paule

AU - Grossman, Ashley B

AU - Taïeb, David

AU - Maher, Eamonn R

AU - Lenders, Jacques W M

AU - Eisenhofer, Graeme

AU - Jimenez, Camilo

AU - Pacak, Karel

AU - Pamporaki, Christina

PY - 2024

Y1 - 2024

N2 - Phaeochromocytomas and paragangliomas (PPGL) are rare neuroendocrine tumours that arise not only in adulthood but also in childhood and adolescence. Up to 70–80% of childhood PPGL are hereditary, accounting for a higher incidence of metastatic and/or multifocal PPGL in paediatric patients than in adult patients. Key differences in the tumour biology and management, together with rare disease incidence and therapeutic challenges in paediatric compared with adult patients, mandate close expert cross-disciplinary teamwork. Teams should ideally include adult and paediatric endocrinologists, oncologists, cardiologists, surgeons, geneticists, pathologists, radiologists, clinical psychologists and nuclear medicine physicians. Provision of an international Consensus Statement should improve care and outcomes for children and adolescents with these tumours.

AB - Phaeochromocytomas and paragangliomas (PPGL) are rare neuroendocrine tumours that arise not only in adulthood but also in childhood and adolescence. Up to 70–80% of childhood PPGL are hereditary, accounting for a higher incidence of metastatic and/or multifocal PPGL in paediatric patients than in adult patients. Key differences in the tumour biology and management, together with rare disease incidence and therapeutic challenges in paediatric compared with adult patients, mandate close expert cross-disciplinary teamwork. Teams should ideally include adult and paediatric endocrinologists, oncologists, cardiologists, surgeons, geneticists, pathologists, radiologists, clinical psychologists and nuclear medicine physicians. Provision of an international Consensus Statement should improve care and outcomes for children and adolescents with these tumours.

KW - phaeochromocytoma

KW - paraganglioma in children

KW - phaeochromocytoma

KW - paraganglioma in children

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U2 - 10.1038/s41574-024-01024-5

DO - 10.1038/s41574-024-01024-5

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ER -

International consensus statement on the diagnosis and management of phaeochromocytoma and paraganglioma in children and adolescents

Abstract

OSS delle Nazioni Unite

All Science Journal Classification (ASJC) codes

Keywords

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