Interleukin-17 in atherosclerosis and cardiovascular disease: the good, the bad, and the unknown

Giovanna Liuzzo, Daniela Pedicino

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

52 Citazioni (Scopus)

Abstract

Over the past few years our understanding of the importance of adaptive immunity in acute coronary syndromes (ACS) has considerably increased. Profound abnormalities have been observed in specific subsets of CD4+T cells, including type 1 helper T (Th1) cells,CD4+CD28nullT cells, and naturally occurring regulatory T cells (Treg cells). Recently a new lineage of CD4+T cells, type 17 helper T (Th17) cells producing the signature cytokines interleukin (IL)-17, IL-21, and IL-22, has been identified. This has fundamentally changed the Th1/Th2 dichotomy paradigm.
Lingua originaleEnglish
pagine (da-a)556-559
Numero di pagine4
RivistaEuropean Heart Journal
Volume34
DOI
Stato di pubblicazionePubblicato - 2013

Keywords

  • Acute Coronary Syndromes
  • Atherosclerosis
  • Immune system
  • Interleukin-17

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