Interleukin-17 in atherosclerosis and cardiovascular disease: the good, the bad, and the unknown

Giovanna Liuzzo

doi:10.1093/eurheartj/ehs399

Interleukin-17 in atherosclerosis and cardiovascular disease: the good, the bad, and the unknown

Giovanna Liuzzo

Risultato della ricerca: Contributo in rivista › Editoriale in rivista / quotidiano › peer review

53 Citazioni (Scopus)

Abstract

Over the past few years our understanding of the importance of adaptive immunity in acute coronary syndromes (ACS) has considerably increased. Profound abnormalities have been observed in specific subsets of CD4+T cells, including type 1 helper T (Th1) cells, CD4+CD28nullT cells, and naturally occurring regulatory T cells (Treg cells). Recently a new lineage of CD4+T cells, type 17 helper T (Th17) cells producing the signature cytokines interleukin (IL)-17, IL-21, and IL-22, has been identified. This has fundamentally changed the Th1/Th2 dichotomy paradigm.

Lingua originale	English
pagine (da-a)	556-559
Numero di pagine	4
Rivista	European Heart Journal
Volume	34
DOI	https://doi.org/10.1093/eurheartj/ehs399
Stato di pubblicazione	Pubblicato - 2013

Keywords

Interleukin-17
atherosclerosis

Accesso al documento

10.1093/eurheartj/ehs399

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N2 - Over the past few years our understanding of the importance of adaptive immunity in acute coronary syndromes (ACS) has considerably increased. Profound abnormalities have been observed in specific subsets of CD4+T cells, including type 1 helper T (Th1) cells, CD4+CD28nullT cells, and naturally occurring regulatory T cells (Treg cells). Recently a new lineage of CD4+T cells, type 17 helper T (Th17) cells producing the signature cytokines interleukin (IL)-17, IL-21, and IL-22, has been identified. This has fundamentally changed the Th1/Th2 dichotomy paradigm.

AB - Over the past few years our understanding of the importance of adaptive immunity in acute coronary syndromes (ACS) has considerably increased. Profound abnormalities have been observed in specific subsets of CD4+T cells, including type 1 helper T (Th1) cells, CD4+CD28nullT cells, and naturally occurring regulatory T cells (Treg cells). Recently a new lineage of CD4+T cells, type 17 helper T (Th17) cells producing the signature cytokines interleukin (IL)-17, IL-21, and IL-22, has been identified. This has fundamentally changed the Th1/Th2 dichotomy paradigm.

KW - Interleukin-17

KW - atherosclerosis

KW - Interleukin-17

KW - atherosclerosis

UR - http://hdl.handle.net/10807/42625

U2 - 10.1093/eurheartj/ehs399

DO - 10.1093/eurheartj/ehs399

M3 - Editorial

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EP - 559

JO - European Heart Journal

JF - European Heart Journal

SN - 0195-668X

ER -