TY - JOUR
T1 - Interleukin-1 as a common denominator from autoinflammatory to autoimmune disorders: premises, perils, and perspectives
AU - Lopalco, Giuseppe
AU - Cantarini, Luca
AU - Vitale, Antonio
AU - Iannone, Florenzo
AU - Anelli, Maria Grazia
AU - Andreozzi, Laura
AU - Lapadula, Giovanni
AU - Galeazzi, Mauro
AU - Rigante, Donato
PY - 2015
Y1 - 2015
N2 - A complex web of dynamic relationships between innate and adaptive immunity is now evident for many autoinflammatory and autoimmune disorders, the first deriving from abnormal activation of innate immune system without any conventional danger triggers and the latter from self-/non-self-discrimination loss of tolerance, and systemic inflammation. Due to clinical and pathophysiologic similarities giving a crucial role to the multifunctional cytokine interleukin-1, the concept of autoinflammation has been expanded to include nonhereditary collagen-like diseases, idiopathic inflammatory diseases, and metabolic diseases. As more patients are reported to have clinical features of autoinflammation and autoimmunity, the boundary between these two pathologic ends is becoming blurred. An overview of monogenic autoinflammatory disorders, PFAPA syndrome, rheumatoid arthritis, type 2 diabetes mellitus, uveitis, pericarditis, Behçet's disease, gout, Sjögren's syndrome, interstitial lung diseases, and Still's disease is presented to highlight the fundamental points that interleukin-1 displays in the cryptic interplay between innate and adaptive immune systems.
AB - A complex web of dynamic relationships between innate and adaptive immunity is now evident for many autoinflammatory and autoimmune disorders, the first deriving from abnormal activation of innate immune system without any conventional danger triggers and the latter from self-/non-self-discrimination loss of tolerance, and systemic inflammation. Due to clinical and pathophysiologic similarities giving a crucial role to the multifunctional cytokine interleukin-1, the concept of autoinflammation has been expanded to include nonhereditary collagen-like diseases, idiopathic inflammatory diseases, and metabolic diseases. As more patients are reported to have clinical features of autoinflammation and autoimmunity, the boundary between these two pathologic ends is becoming blurred. An overview of monogenic autoinflammatory disorders, PFAPA syndrome, rheumatoid arthritis, type 2 diabetes mellitus, uveitis, pericarditis, Behçet's disease, gout, Sjögren's syndrome, interstitial lung diseases, and Still's disease is presented to highlight the fundamental points that interleukin-1 displays in the cryptic interplay between innate and adaptive immune systems.
KW - Autoinflammation
KW - Autoinflammation
UR - http://hdl.handle.net/10807/68763
U2 - 10.1155/2015/194864
DO - 10.1155/2015/194864
M3 - Article
SN - 0962-9351
VL - 2015
SP - N/A-N/A
JO - Mediators of Inflammation
JF - Mediators of Inflammation
ER -