Interleukin 1β receptor and synaptic dysfunction in recurrent brain infection with Herpes simplex virus type-1

Roberto Piacentini*, Claudio Grassi

*Autore corrispondente per questo lavoro

Risultato della ricerca: Contributo in rivistaArticolo in rivista

Abstract

Several experimental evidence suggests a link between brain Herpes simplex virus type-1 infection and the occurrence of Alzheimer's disease. However, the molecular mechanisms underlying this association are not completely understood. Among the molecular mediators of synaptic and cognitive dysfunction occurring after Herpes simplex virus type-1 infection and reactivation in the brain neuroinflammatory cytokines seem to occupy a central role. Here, we specifically reviewed literature reports dealing with the impact of neuroinflammation on synaptic dysfunction observed after recurrent Herpes simplex virus type-1 reactivation in the brain, highlighting the role of interleukins and, in particular, interleukin 1 beta as a possible target against Herpes simplex virus type-1-induced neuronal dysfunctions.
Lingua originaleEnglish
pagine (da-a)416-423
Numero di pagine8
RivistaNeural Regeneration Research
Volume20
DOI
Stato di pubblicazionePubblicato - 2025

Keywords

  • herpes simplex virus type 1
  • interleukin 1 beta
  • synaptic dysfunction
  • neuroinflammation
  • microglia

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