Interactions between antiepileptic and chemoterapeutic drugs in children with brain tumors: is it time to change treatment?

Antonio Ruggiero, Stefano Mastrangelo, Domenica Immacolata Battaglia, Daniela Rizzo, Giorgio Attina', Riccardo Riccardi

Risultato della ricerca: Contributo in rivistaArticolo in rivista

31 Citazioni (Scopus)

Abstract

Epileptic seizures are a common clinical problem in children with brain tumors. The conventional antiepileptic drugs (AEDs) permit a good seizure control in most of these children. An emerging problem is the possible interactions between AEDs and chemotherapeutic drugs, because many of these drugs are metabolized by the cytochrome P450. The aim of this article is to propose a novel therapeutic approach for new-onset epilepsy in children with brain tumors. Among the new AEDs not metabolized by the P450 system, levetiracetam seems to be a promising AED owing to its pharmacokinetic features, efficacy, and safety
Lingua originaleEnglish
pagine (da-a)193-198
Numero di pagine6
RivistaPEDIATRIC BLOOD & CANCER
Volume54
Stato di pubblicazionePubblicato - 2010

Keywords

  • antiepileptic
  • brain tumors
  • chemotherapy
  • children

Fingerprint Entra nei temi di ricerca di 'Interactions between antiepileptic and chemoterapeutic drugs in children with brain tumors: is it time to change treatment?'. Insieme formano una fingerprint unica.

Cita questo