TY - JOUR
T1 - Integrative systems medicine approaches to identify molecular targets in lymphoid malignancies
AU - Frazzi, Raffaele
AU - Auffray, Charles
AU - Ferrari, Angela
AU - Filippini, Perla
AU - Rutella, Sergio
AU - Cesario, Alfredo
PY - 2016
Y1 - 2016
N2 - Although survival rates for lymphoproliferative disorders are steadily increasing both in the US and in Europe, there is need for optimizing front-line therapies and developing more effective salvage strategies. Recent advances in molecular genetics have highlighted the biological diversity of lymphoproliferative disorders. In particular, integrative approaches including whole genome sequencing, whole exome sequencing, and transcriptome or RNA sequencing have been instrumental to the identification of molecular targets for treatment. Herein, we will discuss how genomic, epigenomic and proteomic approaches in lymphoproliferative disorders have supported the discovery of molecular lesions and their therapeutic targeting in the clinic.
AB - Although survival rates for lymphoproliferative disorders are steadily increasing both in the US and in Europe, there is need for optimizing front-line therapies and developing more effective salvage strategies. Recent advances in molecular genetics have highlighted the biological diversity of lymphoproliferative disorders. In particular, integrative approaches including whole genome sequencing, whole exome sequencing, and transcriptome or RNA sequencing have been instrumental to the identification of molecular targets for treatment. Herein, we will discuss how genomic, epigenomic and proteomic approaches in lymphoproliferative disorders have supported the discovery of molecular lesions and their therapeutic targeting in the clinic.
KW - Biochemistry
KW - Genetics and Molecular Biology (all)
KW - High throughput RNA sequencing
KW - Lymphoproliferative disorder
KW - Massively-Parallel sequencing
KW - Medicine (all)
KW - Systems medicine
KW - Biochemistry
KW - Genetics and Molecular Biology (all)
KW - High throughput RNA sequencing
KW - Lymphoproliferative disorder
KW - Massively-Parallel sequencing
KW - Medicine (all)
KW - Systems medicine
UR - https://publicatt.unicatt.it/handle/10807/99986
UR - https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=84984671956&origin=inward
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84984671956&origin=inward
U2 - 10.1186/s12967-016-1018-2
DO - 10.1186/s12967-016-1018-2
M3 - Article
SN - 1479-5876
VL - 14
SP - 252
EP - 252
JO - Journal of Translational Medicine
JF - Journal of Translational Medicine
IS - 1
ER -