Integrative systems medicine approaches to identify molecular targets in lymphoid malignancies

Sergio Rutella, Alfredo Cesario, Raffaele Frazzi, Charles Auffray, Angela Ferrari, Perla Filippini

Risultato della ricerca: Contributo in rivistaArticolo in rivista

2 Citazioni (Scopus)

Abstract

Although survival rates for lymphoproliferative disorders are steadily increasing both in the US and in Europe, there is need for optimizing front-line therapies and developing more effective salvage strategies. Recent advances in molecular genetics have highlighted the biological diversity of lymphoproliferative disorders. In particular, integrative approaches including whole genome sequencing, whole exome sequencing, and transcriptome or RNA sequencing have been instrumental to the identification of molecular targets for treatment. Herein, we will discuss how genomic, epigenomic and proteomic approaches in lymphoproliferative disorders have supported the discovery of molecular lesions and their therapeutic targeting in the clinic.
Lingua originaleEnglish
pagine (da-a)252-252
Numero di pagine1
RivistaJournal of Translational Medicine
Volume14
DOI
Stato di pubblicazionePubblicato - 2016

Keywords

  • Biochemistry, Genetics and Molecular Biology (all)
  • High throughput RNA sequencing
  • Lymphoproliferative disorder
  • Massively-Parallel sequencing
  • Medicine (all)
  • Systems medicine

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