Insulin resistance alters islet morphology in nondiabetic humans

Teresa Mezza, Gennaro Clemente, Alfredo Pontecorvi, Andrea Giaccari, Gianpio Sorice, Jiang Hu, Jens J. Holst, Rohit N. Kulkarni

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

103 Citazioni (Scopus)

Abstract

Type 2 diabetes is characterized by poor glucose uptake in metabolic tissues and manifests when insulin secretion fails to cope with worsening insulin resistance. In addition to its effects on skeletal muscle, liver, and adipose tissue metabolism, it is evident that insulin resistance also affects pancreatic β-cells. To directly examine the alterations that occur in islet morphology as part of an adaptive mechanism to insulin resistance, we evaluated pancreas samples obtained during pancreatoduodenectomy from nondiabetic subjects who were insulin-resistant or insulin-sensitive. We also compared insulin sensitivity, insulin secretion, and incretin levels between the two groups. We report an increased islet size and an elevated number of β- and α-cells that resulted in an altered β-cell-to-α-cell area in the insulin- resistant group. Our data in this series of studies suggest that neogenesis from duct cells and transdifferentiation of α-cells are potential contributors to the β-cell compensatory response to insulin resistance in the absence of overt diabetes.
Lingua originaleEnglish
pagine (da-a)994-1007
Numero di pagine14
RivistaDiabetes
Volume63
DOI
Stato di pubblicazionePubblicato - 2014

Keywords

  • beta cells
  • beta cellule
  • insulin resistance
  • insulin secretion
  • insulino resistenza
  • isole pancreatiche
  • neogenesi
  • neogenesis
  • pancreatic islets
  • secrezione insulinica
  • transdifferentiation
  • transdifferenziazione

Fingerprint Entra nei temi di ricerca di 'Insulin resistance alters islet morphology in nondiabetic humans'. Insieme formano una fingerprint unica.

Cita questo