Innovative quantitative testing of hand function in Charcot-Marie-Tooth neuropathy

Luca Padua, Maria A. Alberti, Laura Mori, Luca Francini, Ilaria Poggi, Margherita Monti Bragadin, Emilia Bellone, Marina Grandis, Giovanni Maggi, Lizia Reni, Maria P. Sormani, Andrea Tacchino, Valeria Prada, Marco Bove, Angelo Schenone

Risultato della ricerca: Contributo in rivistaArticolo in rivista

5 Citazioni (Scopus)

Abstract

OBJECTIVE: To describe a new test to quantitatively evaluate hand function in patients affected by Charcot-Marie-Tooth neuropathy (CMT). METHODS: The sensor engineered glove test (SEGT) was applied to CMT patients (N: 26) and compared to a cohort of healthy controls (HC, N: 26). CMT patients were further divided into subjects with clinically normal (group 1) or impaired hand (group 2) function. The SEGT parameters evaluated were Touch Duration (TD), Inter-tapping interval (ITI) and movement rate parameters of two different sequences: Finger Tapping (FT) and Index-Medium-Ring- Little (IMRL) performed at self-paced mode (SPM) and maximum velocity (MV). Hand function and strength were assessed by the 9 hole-peg-test (9HPT) and dynamometry. Disability of patients was measured by the CMT neuropathy score (CMTNS). RESULTS: CMT patients had significantly worst performances at SEGT than controls regarding the rate of execution of both FT (at MV) and IMRL sequences (at SPM and MV). The rate parameter at MV in IMRL sequence showed a significant trend of decreasing in its average between HC (n. 26, rate = 3.08, ±0.52 Hz), group 1 (n. 9, rate = 2.64, ±0.66) and group 2 (n. 17, rate = 2.19, ±0.45) (p for trend < 0.001). No correlations were found with either 9HPT, dynamometry, electrophysiology and the CMT neuropathy score. CONCLUSIONS: The SEGT test is sensitive to show hand dysfunction in CMT patients, with and without clinically impaired hands. This article is protected by copyright. All rights reserved.
Lingua originaleEnglish
pagine (da-a)410-414
Numero di pagine5
RivistaJournal of the Peripheral Nervous System
Volume20
DOI
Stato di pubblicazionePubblicato - 2015

Keywords

  • Charcot-Marie-Tooth
  • hand dexterity
  • hand strength
  • sensory engineered glove test

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