Inhibitor effect of antioxidant flavonoids quercitin and capsaicin in mast cell inflammation

Franco Pandolfi, Y. B. Shaik-Dasthagirisaheb, G. Varvara, G. Murmura, A. Saggini, A. Caraffa, P. Antinolfi, S. Tetè, M. Rosati, E. Cianchetti, E. Toniato, L. Speranza, A. Pantalone, R. Saggini, L. M. Di Tommaso, P. Conti, T. C. Theoharides

Risultato della ricerca: Contributo in rivistaArticolo in rivista

5 Citazioni (Scopus)

Abstract

Mast cells are essential not only for allergies but also for innate and acquired immunity, autoimmunity and inflammation, and they are recognized as a new type of immunoregulatory cells capable of producing different cytokines. Natural compounds have long been recognized to possess anti-inflammatory, antioxidant and anticancergenic activity. Quercitin is an inhibitor for mast cells and is a potent antioxidant, cytoprotective and anti-inflammatory compound and has a negative effect on intracellular regulator signal events initiated by FceRI receptor cross-linking and other activating receptors on mast cells. These observations candidate quercitin as a therapeutic compound in association with other therapeutic molecules. Capsaicin is a compound derived from peppers, especially capsicum, and is involved in stimulating circulation aiding digestion and relieving pain. Capsaicin receptor sub type I (VRI) is expressing in neurons and is present in a number of brain nuclei and in non-neuronal tissues, mediating inflammatory response. Capsaicin is involved in migraine, allergic symptoms, arthritis pain and gastric secretion. In this paper we review the biological effects of quercitin and capsaicin.
Lingua originaleEnglish
pagine (da-a)N/A-N/A
RivistaEuropean Journal of Inflammation
Stato di pubblicazionePubblicato - 2013

Keywords

  • mast cells

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