TY - JOUR
T1 - Inhibitor effect of antioxidant flavonoids quercitin and capsaicin in mast cell inflammation
AU - Shaik-Dasthagirisaheb, Y. B.
AU - Varvara, G.
AU - Murmura, G.
AU - Saggini, A.
AU - Caraffa, A.
AU - Antinolfi, P.
AU - Tetè, S.
AU - Rosati, M.
AU - Cianchetti, E.
AU - Toniato, E.
AU - Speranza, L.
AU - Pantalone, A.
AU - Saggini, R.
AU - Di Tommaso, L. M.
AU - Conti, P.
AU - Theoharides, T. C.
AU - Pandolfi, Franco
PY - 2013
Y1 - 2013
N2 - Mast cells are essential not only for allergies but also for innate and acquired immunity, autoimmunity and inflammation, and they are recognized as a new type of immunoregulatory cells capable of producing different cytokines. Natural compounds have long been recognized to possess anti-inflammatory, antioxidant and anticancergenic activity. Quercitin is an inhibitor for mast cells and is a potent antioxidant, cytoprotective and anti-inflammatory compound and has a negative effect on intracellular regulator signal events initiated by FceRI receptor cross-linking and other activating receptors on mast cells. These observations candidate quercitin as a therapeutic compound in association with other therapeutic molecules. Capsaicin is a compound derived from peppers, especially capsicum, and is involved in stimulating circulation aiding digestion and relieving pain. Capsaicin receptor sub type I (VRI) is expressing in neurons and is present in a number of brain nuclei and in non-neuronal tissues, mediating inflammatory response. Capsaicin is involved in migraine, allergic symptoms, arthritis pain and gastric secretion. In this paper we review the biological effects of quercitin and capsaicin.
AB - Mast cells are essential not only for allergies but also for innate and acquired immunity, autoimmunity and inflammation, and they are recognized as a new type of immunoregulatory cells capable of producing different cytokines. Natural compounds have long been recognized to possess anti-inflammatory, antioxidant and anticancergenic activity. Quercitin is an inhibitor for mast cells and is a potent antioxidant, cytoprotective and anti-inflammatory compound and has a negative effect on intracellular regulator signal events initiated by FceRI receptor cross-linking and other activating receptors on mast cells. These observations candidate quercitin as a therapeutic compound in association with other therapeutic molecules. Capsaicin is a compound derived from peppers, especially capsicum, and is involved in stimulating circulation aiding digestion and relieving pain. Capsaicin receptor sub type I (VRI) is expressing in neurons and is present in a number of brain nuclei and in non-neuronal tissues, mediating inflammatory response. Capsaicin is involved in migraine, allergic symptoms, arthritis pain and gastric secretion. In this paper we review the biological effects of quercitin and capsaicin.
KW - mast cells
KW - mast cells
UR - http://hdl.handle.net/10807/60588
U2 - 10.1177/1721727X1301100205
DO - 10.1177/1721727X1301100205
M3 - Article
SN - 1721-727X
VL - 11
SP - 353
EP - 357
JO - European Journal of Inflammation
JF - European Journal of Inflammation
ER -