Inhibition of the striatal specific phosphodiesterase PDE10A ameliorates striatal and cortical pathology in R6/2 mouse model of Huntington's disease

Carmela Giampa', D Laurenti, S Anzilotti, G Bernardi, Fs Menniti, Fr Fusco

Risultato della ricerca: Contributo in rivistaArticolo in rivista

142 Citazioni (Scopus)

Abstract

Huntington's disease is a devastating neurodegenerative condition for which there is no therapy to slow disease progression. The particular vulnerability of striatal medium spiny neurons to Huntington's pathology is hypothesized to result from transcriptional dysregulation within the cAMP and CREB signaling cascades in these neurons. To test this hypothesis, and a potential therapeutic approach, we investigated whether inhibition of the striatal-specific cyclic nucleotide phosphodiesterase PDE10A would alleviate neurological deficits and brain pathology in a highly utilized model system, the R6/2 mouse.
Lingua originaleEnglish
pagine (da-a)e13417-e13417
RivistaPLoS One
Volume5
DOI
Stato di pubblicazionePubblicato - 2010

Keywords

  • Animals
  • Corpus Striatum
  • Disease Models, Animal
  • Huntington Disease
  • Immunohistochemistry
  • Mice
  • Phosphodiesterase Inhibitors
  • Phosphoric Diester Hydrolases
  • Pyrazoles
  • Quinolines

Fingerprint

Entra nei temi di ricerca di 'Inhibition of the striatal specific phosphodiesterase PDE10A ameliorates striatal and cortical pathology in R6/2 mouse model of Huntington's disease'. Insieme formano una fingerprint unica.

Cita questo