INfluenza Vaccine Indication During therapy with Immune checkpoint inhibitors: a transversal challenge. The INVIDIa study.

Melissa Bersanelli; Diana Giannarelli; Paola Castrignanò; Giuseppe Fornarini; Stefano Panni; Francesca Mazzoni; Marcello Tiseo; Sabrina Rossetti; Elisabetta Gambale; Ernesto Rossi; Anselmo Papa; Alessio Cortellini; Cristian Lolli; Raffaele Ratta; Maria Michiara; Michele Milella; Emmanuele De Luca; Mariella Sorarù; Claudia Mucciarini; Francesco Atzori; Giuseppe L Banna; Leonardo La Torre; Maria G Vitale; Francesco Massari; Sara E Rebuzzi; Gaetano Facchini; Giovanni Schinzari; Silverio Tomao; Simona Bui; Vanja Vaccaro; Giuseppe Procopio; Ugo De Giorgi; Matteo Santoni; Corrado Ficorella; Roberto Sabbatini; Antonio Maestri; Clara Natoli; Michele De Tursi; Massimo Di Maio; Elena Rapacchi; Annagrazia Pireddu; Teodoro Sava; Helga Lipari; Francesca Comito; Elena Verzoni; Francesco Leonardi; Sebastiano Buti

doi:10.2217/imt-2018-0080

INfluenza Vaccine Indication During therapy with Immune checkpoint inhibitors: a transversal challenge. The INVIDIa study.

Melissa Bersanelli, Diana Giannarelli, Paola Castrignanò, Giuseppe Fornarini, Stefano Panni, Francesca Mazzoni, Marcello Tiseo, Sabrina Rossetti, Elisabetta Gambale, Ernesto Rossi, Anselmo Papa, Alessio Cortellini, Cristian Lolli, Raffaele Ratta, Maria Michiara, Michele Milella, Emmanuele De Luca, Mariella Sorarù, Claudia Mucciarini, Francesco AtzoriGiuseppe L Banna, Leonardo La Torre, Maria G Vitale, Francesco Massari, Sara E Rebuzzi, Gaetano Facchini, Giovanni Schinzari, Silverio Tomao, Simona Bui, Vanja Vaccaro, Giuseppe Procopio, Ugo De Giorgi, Matteo Santoni, Corrado Ficorella, Roberto Sabbatini, Antonio Maestri, Clara Natoli, Michele De Tursi, Massimo Di Maio, Elena Rapacchi, Annagrazia Pireddu, Teodoro Sava, Helga Lipari, Francesca Comito, Elena Verzoni, Francesco Leonardi, Sebastiano Buti

Risultato della ricerca: Contributo in rivista › Articolo in rivista

20 Citazioni (Scopus)

Abstract

AIM: Considering the unmet need for the counseling of cancer patients treated with immune checkpoint inhibitors (CKI) about influenza vaccination, an explorative study was planned to assess flu vaccine efficacy in this population. METHODS: INVIDIa was a retrospective, multicenter study, enrolling consecutive advanced cancer outpatients receiving CKI during the influenza season 2016-2017. RESULTS: Of 300 patients, 79 received flu vaccine. The incidence of influenza syndrome was 24.1% among vaccinated, versus 11.8% of controls; odds ratio: 2.4; 95% CI: 1.23-4.59; p = 0.009. The clinical ineffectiveness of vaccine was more pronounced among elderly: 37.8% among vaccinated patients, versus 6.1% of unvaccinated, odds ratio: 9.28; 95% CI: 2.77-31.14; p < 0.0001. CONCLUSION: Although influenza vaccine may be clinically ineffective in advanced cancer patients receiving CKI, it seems not to negatively impact the efficacy of anticancer therapy.

Lingua originale	English
pagine (da-a)	1229-1239
Numero di pagine	11
Rivista	Immunotherapy
DOI	https://doi.org/10.2217/imt-2018-0080
Stato di pubblicazione	Pubblicato - 2018

Keywords

immune checkpoint inhibitors
influenza syndrome

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Bersanelli, M., Giannarelli, D., Castrignanò, P., Fornarini, G., Panni, S., Mazzoni, F., Tiseo, M., Rossetti, S., Gambale, E., Rossi, E., Papa, A., Cortellini, A., Lolli, C., Ratta, R., Michiara, M., Milella, M., Luca, E. D., Sorarù, M., Mucciarini, C., ... Buti, S. (2018). INfluenza Vaccine Indication During therapy with Immune checkpoint inhibitors: a transversal challenge. The INVIDIa study. Immunotherapy, 1229-1239. https://doi.org/10.2217/imt-2018-0080

@article{8f3ce50e025d45b2ac2586fc04457372,

title = "INfluenza Vaccine Indication During therapy with Immune checkpoint inhibitors: a transversal challenge. The INVIDIa study.",

abstract = "AIM: Considering the unmet need for the counseling of cancer patients treated with immune checkpoint inhibitors (CKI) about influenza vaccination, an explorative study was planned to assess flu vaccine efficacy in this population. METHODS: INVIDIa was a retrospective, multicenter study, enrolling consecutive advanced cancer outpatients receiving CKI during the influenza season 2016-2017. RESULTS: Of 300 patients, 79 received flu vaccine. The incidence of influenza syndrome was 24.1% among vaccinated, versus 11.8% of controls; odds ratio: 2.4; 95% CI: 1.23-4.59; p = 0.009. The clinical ineffectiveness of vaccine was more pronounced among elderly: 37.8% among vaccinated patients, versus 6.1% of unvaccinated, odds ratio: 9.28; 95% CI: 2.77-31.14; p < 0.0001. CONCLUSION: Although influenza vaccine may be clinically ineffective in advanced cancer patients receiving CKI, it seems not to negatively impact the efficacy of anticancer therapy.",

keywords = "immune checkpoint inhibitors, influenza syndrome, immune checkpoint inhibitors, influenza syndrome",

author = "Melissa Bersanelli and Diana Giannarelli and Paola Castrignan{\`o} and Giuseppe Fornarini and Stefano Panni and Francesca Mazzoni and Marcello Tiseo and Sabrina Rossetti and Elisabetta Gambale and Ernesto Rossi and Anselmo Papa and Alessio Cortellini and Cristian Lolli and Raffaele Ratta and Maria Michiara and Michele Milella and Luca, {Emmanuele De} and Mariella Sorar{\`u} and Claudia Mucciarini and Francesco Atzori and Banna, {Giuseppe L} and Torre, {Leonardo La} and Vitale, {Maria G} and Francesco Massari and Rebuzzi, {Sara E} and Gaetano Facchini and Giovanni Schinzari and Silverio Tomao and Simona Bui and Vanja Vaccaro and Giuseppe Procopio and Giorgi, {Ugo De} and Matteo Santoni and Corrado Ficorella and Roberto Sabbatini and Antonio Maestri and Clara Natoli and Tursi, {Michele De} and Maio, {Massimo Di} and Elena Rapacchi and Annagrazia Pireddu and Teodoro Sava and Helga Lipari and Francesca Comito and Elena Verzoni and Francesco Leonardi and Sebastiano Buti",

year = "2018",

doi = "10.2217/imt-2018-0080",

language = "English",

pages = "1229--1239",

journal = "Immunotherapy",

issn = "1750-743X",

publisher = "London : Future Medicine, 2009-",

}

Bersanelli, M, Giannarelli, D, Castrignanò, P, Fornarini, G, Panni, S, Mazzoni, F, Tiseo, M, Rossetti, S, Gambale, E, Rossi, E, Papa, A, Cortellini, A, Lolli, C, Ratta, R, Michiara, M, Milella, M, Luca, ED, Sorarù, M, Mucciarini, C, Atzori, F, Banna, GL, Torre, LL, Vitale, MG, Massari, F, Rebuzzi, SE, Facchini, G, Schinzari, G, Tomao, S, Bui, S, Vaccaro, V, Procopio, G, Giorgi, UD, Santoni, M, Ficorella, C, Sabbatini, R, Maestri, A, Natoli, C, Tursi, MD, Maio, MD, Rapacchi, E, Pireddu, A, Sava, T, Lipari, H, Comito, F, Verzoni, E, Leonardi, F & Buti, S 2018, 'INfluenza Vaccine Indication During therapy with Immune checkpoint inhibitors: a transversal challenge. The INVIDIa study.', Immunotherapy, pagg. 1229-1239. https://doi.org/10.2217/imt-2018-0080

TY - JOUR

T1 - INfluenza Vaccine Indication During therapy with Immune checkpoint inhibitors: a transversal challenge. The INVIDIa study.

AU - Bersanelli, Melissa

AU - Giannarelli, Diana

AU - Castrignanò, Paola

AU - Fornarini, Giuseppe

AU - Panni, Stefano

AU - Mazzoni, Francesca

AU - Tiseo, Marcello

AU - Rossetti, Sabrina

AU - Gambale, Elisabetta

AU - Rossi, Ernesto

AU - Papa, Anselmo

AU - Cortellini, Alessio

AU - Lolli, Cristian

AU - Ratta, Raffaele

AU - Michiara, Maria

AU - Milella, Michele

AU - Luca, Emmanuele De

AU - Sorarù, Mariella

AU - Mucciarini, Claudia

AU - Atzori, Francesco

AU - Banna, Giuseppe L

AU - Torre, Leonardo La

AU - Vitale, Maria G

AU - Massari, Francesco

AU - Rebuzzi, Sara E

AU - Facchini, Gaetano

AU - Schinzari, Giovanni

AU - Tomao, Silverio

AU - Bui, Simona

AU - Vaccaro, Vanja

AU - Procopio, Giuseppe

AU - Giorgi, Ugo De

AU - Santoni, Matteo

AU - Ficorella, Corrado

AU - Sabbatini, Roberto

AU - Maestri, Antonio

AU - Natoli, Clara

AU - Tursi, Michele De

AU - Maio, Massimo Di

AU - Rapacchi, Elena

AU - Pireddu, Annagrazia

AU - Sava, Teodoro

AU - Lipari, Helga

AU - Comito, Francesca

AU - Verzoni, Elena

AU - Leonardi, Francesco

AU - Buti, Sebastiano

PY - 2018

Y1 - 2018

N2 - AIM: Considering the unmet need for the counseling of cancer patients treated with immune checkpoint inhibitors (CKI) about influenza vaccination, an explorative study was planned to assess flu vaccine efficacy in this population. METHODS: INVIDIa was a retrospective, multicenter study, enrolling consecutive advanced cancer outpatients receiving CKI during the influenza season 2016-2017. RESULTS: Of 300 patients, 79 received flu vaccine. The incidence of influenza syndrome was 24.1% among vaccinated, versus 11.8% of controls; odds ratio: 2.4; 95% CI: 1.23-4.59; p = 0.009. The clinical ineffectiveness of vaccine was more pronounced among elderly: 37.8% among vaccinated patients, versus 6.1% of unvaccinated, odds ratio: 9.28; 95% CI: 2.77-31.14; p < 0.0001. CONCLUSION: Although influenza vaccine may be clinically ineffective in advanced cancer patients receiving CKI, it seems not to negatively impact the efficacy of anticancer therapy.

AB - AIM: Considering the unmet need for the counseling of cancer patients treated with immune checkpoint inhibitors (CKI) about influenza vaccination, an explorative study was planned to assess flu vaccine efficacy in this population. METHODS: INVIDIa was a retrospective, multicenter study, enrolling consecutive advanced cancer outpatients receiving CKI during the influenza season 2016-2017. RESULTS: Of 300 patients, 79 received flu vaccine. The incidence of influenza syndrome was 24.1% among vaccinated, versus 11.8% of controls; odds ratio: 2.4; 95% CI: 1.23-4.59; p = 0.009. The clinical ineffectiveness of vaccine was more pronounced among elderly: 37.8% among vaccinated patients, versus 6.1% of unvaccinated, odds ratio: 9.28; 95% CI: 2.77-31.14; p < 0.0001. CONCLUSION: Although influenza vaccine may be clinically ineffective in advanced cancer patients receiving CKI, it seems not to negatively impact the efficacy of anticancer therapy.

KW - immune checkpoint inhibitors

KW - influenza syndrome

KW - immune checkpoint inhibitors

KW - influenza syndrome

UR - http://hdl.handle.net/10807/134547

U2 - 10.2217/imt-2018-0080

DO - 10.2217/imt-2018-0080

M3 - Article

SN - 1750-743X

SP - 1229

EP - 1239

JO - Immunotherapy

JF - Immunotherapy

ER -

INfluenza Vaccine Indication During therapy with Immune checkpoint inhibitors: a transversal challenge. The INVIDIa study.

Abstract

Keywords

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