INfluenza Vaccine Indication During therapy with Immune checkpoint inhibitors: a transversal challenge. The INVIDIa study.

Giovanni Schinzari, Ernesto Rossi, Melissa Bersanelli, Diana Giannarelli, Paola Castrignanò, Giuseppe Fornarini, Stefano Panni, Francesca Mazzoni, Marcello Tiseo, Sabrina Rossetti, Elisabetta Gambale, Anselmo Papa, Alessio Cortellini, Cristian Lolli, Raffaele Ratta, Maria Michiara, Michele Milella, Emmanuele De Luca, Mariella Sorarù, Claudia MucciariniFrancesco Atzori, Giuseppe L Banna, Leonardo La Torre, Maria G Vitale, Francesco Massari, Sara E Rebuzzi, Gaetano Facchini, Silverio Tomao, Simona Bui, Vanja Vaccaro, Giuseppe Procopio, Ugo De Giorgi, Matteo Santoni, Corrado Ficorella, Roberto Sabbatini, Antonio Maestri, Clara Natoli, Michele De Tursi, Massimo Di Maio, Elena Rapacchi, Annagrazia Pireddu, Teodoro Sava, Helga Lipari, Francesca Comito, Elena Verzoni, Francesco Leonardi, Sebastiano Buti

Risultato della ricerca: Contributo in rivistaArticolo in rivista

20 Citazioni (Scopus)

Abstract

AIM: Considering the unmet need for the counseling of cancer patients treated with immune checkpoint inhibitors (CKI) about influenza vaccination, an explorative study was planned to assess flu vaccine efficacy in this population. METHODS: INVIDIa was a retrospective, multicenter study, enrolling consecutive advanced cancer outpatients receiving CKI during the influenza season 2016-2017. RESULTS: Of 300 patients, 79 received flu vaccine. The incidence of influenza syndrome was 24.1% among vaccinated, versus 11.8% of controls; odds ratio: 2.4; 95% CI: 1.23-4.59; p = 0.009. The clinical ineffectiveness of vaccine was more pronounced among elderly: 37.8% among vaccinated patients, versus 6.1% of unvaccinated, odds ratio: 9.28; 95% CI: 2.77-31.14; p < 0.0001. CONCLUSION: Although influenza vaccine may be clinically ineffective in advanced cancer patients receiving CKI, it seems not to negatively impact the efficacy of anticancer therapy.
Lingua originaleEnglish
pagine (da-a)1229-1239
Numero di pagine11
RivistaImmunotherapy
DOI
Stato di pubblicazionePubblicato - 2018

Keywords

  • immune checkpoint inhibitors
  • influenza syndrome

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