TY - JOUR
T1 - Influence of 5-HTTLPR polymorphism on postpartum depressive and posttraumatic symptoms
AU - Landoni, Marta
AU - Missaglia, Sara
AU - Tavian, Daniela
AU - Ionio, Chiara
AU - Di Blasio, Paola
PY - 2022
Y1 - 2022
N2 - Introduction Postpartum depression (PPD) is a multifactor disorder caused by psychological, social, and also biological factors. 5-HTTLPR polymorphism in the promoter region of serotonin transporter gene seems to influence PPD onset. In this study, we examined the effect of 5-HTTLPR polymorphism on prenatal and postnatal symptoms of depression and posttraumatic stress in women. Methods A longitudinal design with three points - time 1 (32-40 weeks gestation); time 2 (2 or 3 weeks after birth), and time 3 (3 months after birth) - was made. A total of 141 women were recruited during childbirth preparation courses. At time 1, women completed the Beck Depression Inventory (BDI) and the Los Angeles Symptoms Checklist (LASC). At time 2, they fulfilled BDI and Edinburgh Postnatal Depression Scale (EDPS), LASC and the Perinatal Posttraumatic stress disorder (PTSD) Questionnaire (PPQ); midwives and nurses collected biological test tubes by blood sampling for the genetic analysis. At time 3, the women were reassessed for BDI, LASC, EDPS, and PPQs. Analysis of variance and moderation analysis were used to correlate genotype and psychological investigations. Results Results showed that, compared with LL/LS genotypes, SS genotype moderated cognitive depressive symptoms onset at T2 and T3. Moreover, this genotype correlated, directly or indirectly, with PTSD postpartum aspects (re-experience, avoidance, and hyperarousal). Discussion Findings revealed that a lower expression of serotonin transporter gene, associated with SS genotype, seems to render women more vulnerable to depressive and PTSD symptoms after childbirth.
AB - Introduction Postpartum depression (PPD) is a multifactor disorder caused by psychological, social, and also biological factors. 5-HTTLPR polymorphism in the promoter region of serotonin transporter gene seems to influence PPD onset. In this study, we examined the effect of 5-HTTLPR polymorphism on prenatal and postnatal symptoms of depression and posttraumatic stress in women. Methods A longitudinal design with three points - time 1 (32-40 weeks gestation); time 2 (2 or 3 weeks after birth), and time 3 (3 months after birth) - was made. A total of 141 women were recruited during childbirth preparation courses. At time 1, women completed the Beck Depression Inventory (BDI) and the Los Angeles Symptoms Checklist (LASC). At time 2, they fulfilled BDI and Edinburgh Postnatal Depression Scale (EDPS), LASC and the Perinatal Posttraumatic stress disorder (PTSD) Questionnaire (PPQ); midwives and nurses collected biological test tubes by blood sampling for the genetic analysis. At time 3, the women were reassessed for BDI, LASC, EDPS, and PPQs. Analysis of variance and moderation analysis were used to correlate genotype and psychological investigations. Results Results showed that, compared with LL/LS genotypes, SS genotype moderated cognitive depressive symptoms onset at T2 and T3. Moreover, this genotype correlated, directly or indirectly, with PTSD postpartum aspects (re-experience, avoidance, and hyperarousal). Discussion Findings revealed that a lower expression of serotonin transporter gene, associated with SS genotype, seems to render women more vulnerable to depressive and PTSD symptoms after childbirth.
KW - 5-HTTLPR
KW - Delivery
KW - Depression, Postpartum
KW - Female
KW - Humans
KW - Polymorphism, Genetic
KW - Postpartum Period
KW - Postpartum depression
KW - Posttraumatic stress disorder
KW - Pregnancy
KW - Serotonin Plasma Membrane Transport Proteins
KW - Stress Disorders, Post-Traumatic
KW - 5-HTTLPR
KW - Delivery
KW - Depression, Postpartum
KW - Female
KW - Humans
KW - Polymorphism, Genetic
KW - Postpartum Period
KW - Postpartum depression
KW - Posttraumatic stress disorder
KW - Pregnancy
KW - Serotonin Plasma Membrane Transport Proteins
KW - Stress Disorders, Post-Traumatic
UR - http://hdl.handle.net/10807/196342
U2 - 10.1097/YPG.0000000000000299
DO - 10.1097/YPG.0000000000000299
M3 - Article
SN - 0955-8829
VL - 32
SP - 9
EP - 14
JO - Psychiatric Genetics
JF - Psychiatric Genetics
ER -