Inflammasome, T Lymphocytes and Innate-Adaptive Immunity Crosstalk: Role in Cardiovascular Disease and Therapeutic Perspectives

Luigi Marzio Biasucci, Filippo Crea, Giovanna Liuzzo, Daniela Pedicino, Ada Francesca Giglio, Aureliano Ruggio, Alessia D'Aiello, Francesco Trotta, Claudia Lucci, Francesca Graziani

Risultato della ricerca: Contributo in rivistaArticolo in rivista

4 Citazioni (Scopus)

Abstract

Over the past few decades, lot of evidences have shown atherosclerosis as a chronic progressive disease with an exquisite inflammatory feature. More recently, the role of innate immune response in the onset and progression of coronary artery disease (CAD) and an adaptive immunity imbalance, mostly involving T cell sub-sets, have been documented. Therefore, like in many other inflammatory and autoimmune disorders, an altered innate-adaptive immunity crosstalk could represent the key of the inflammatory burden leading to atherosclerotic plaque formation and progression and to the breakdown of plaque stability. In this review, we will address the role of inflammasome in innate immunity and in the imbalance of adaptive immunity. We will discuss how this altered immune crosstalk is related to CAD onset and progression. We will also discuss how unravelling the key molecular mechanisms is of paramount importance in the development of therapeutic tools to delay the chronic progression and prevent the acute destabilization of atherosclerotic plaque.
Lingua originaleEnglish
pagine (da-a)1352-1369
Numero di pagine18
RivistaThrombosis and Haemostasis
Volume118
DOI
Stato di pubblicazionePubblicato - 2018

Keywords

  • Hematology
  • acute coronary syndromes
  • adaptive immunity
  • coronary artery disease
  • inflammasome
  • innate immunity
  • precision medicine

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