Inflammaging at the Time of COVID-19

Maria Beatrice Zazzara, Agnese Bellieni, Riccardo Calvani, Hélio Jose Coelho-Junior, Anna Picca, Emanuele Marzetti

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

Abstract

Inflammaging and SARS-CoV-2 infection interact in an interplay that involves both acute inflammation and low-grade chronic inflammation, predisposing older adults to severe COVID-19. During the acute phase, the precipitating factor is represented by an aberrant immune response characterized by the overproduction of proinflammatory cytokines. Increased cytokine levels may persist long after viral clearance and are potentially responsible for the installment of low-grade chronic inflammation and long-lasting persistence of COVID-19 symptoms. Therapeutic approaches targeting inflammation have proven to be effective in reducing mortality during an acute COVID-19 episode. However, at the time of writing, no standard treatment is available for the postacute phase. Although further research is needed, lifestyle interventions (physical activity and specific nutritional strategies) can effectively counteract chronic inflammation and may therefore be proposed as strategies to mitigate long-term symptom persistence.
Lingua originaleEnglish
pagine (da-a)473-481
Numero di pagine9
RivistaClinics in Geriatric Medicine
Volume38
DOI
Stato di pubblicazionePubblicato - 2022

Keywords

  • Cytokines
  • Diet
  • Immunosenescence
  • Inflammation
  • Long COVID
  • Older adults
  • Physical activity
  • SARS-CoV-2

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