Infections caused by KPC-producing Klebsiella pneumoniae: differences in therapy and mortality in a multicentre study

Mario Tumbarello; Enrico Maria Trecarichi; Francesco Giuseppe De Rosa; Maddalena Giannella; Daniele Roberto Giacobbe; Matteo Bassetti; Angela Raffaella Losito; Michele Bartoletti; Valerio Del Bono; Silvia Corcione; Giuseppe Maiuro; Sara Tedeschi; Luigi Celani; Chiara Simona Cardellino; Teresa Spanu; Anna Marchese; Simone Ambretti; Roberto Cauda; Claudio Viscoli; Pierluigi Viale

doi:10.1093/jac/dkv086

Infections caused by KPC-producing Klebsiella pneumoniae: differences in therapy and mortality in a multicentre study

Mario Tumbarello
, Enrico Maria Trecarichi
, Francesco Giuseppe De Rosa
, Maddalena Giannella
, Daniele Roberto Giacobbe
, Matteo Bassetti
, Angela Raffaella Losito
, Michele Bartoletti
, Valerio Del Bono
, Silvia Corcione
, Giuseppe Maiuro
, Sara Tedeschi
, Luigi Celani
, Chiara Simona Cardellino
, Teresa Spanu
, Anna Marchese
, Simone Ambretti
, Roberto Cauda
, Claudio Viscoli
, Pierluigi Viale

University of Turin
Alma Mater Studiorum University of Bologna
San Martino Hospital Genoa
Santa Maria Misericordia University Hospital

Risultato della ricerca: Contributo in rivista › Articolo

316 Citazioni (Scopus)

Abstract

Infections caused by Klebsiella pneumoniae (Kp) carbapenemase (KPC)-producing strains of Kp have become a significant threat in recent years. To assess their outcomes and identify risk factors for 14 day mortality, we conducted a 4 year (2010-13) retrospective cohort study in five large Italian teaching hospitals.

Lingua originale	Inglese
pagine (da-a)	2133-2143
Numero di pagine	11
Rivista	Journal of Antimicrobial Chemotherapy
Volume	70
DOI	https://doi.org/10.1093/jac/dkv086
Stato di pubblicazione	Pubblicato - 2015

Keywords

carbapenem resistance
carbapenemases
colistin resistance
combination therapy
inadequate empirical therapy
meropenem MICs
treatment

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10.1093/jac/dkv086

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Tumbarello, M., Trecarichi, E. M., De Rosa, F. G., Giannella, M., Giacobbe, D. R., Bassetti, M., Losito, A. R., Bartoletti, M., Del Bono, V., Corcione, S., Maiuro, G., Tedeschi, S., Celani, L., Cardellino, C. S., Spanu, T., Marchese, A., Ambretti, S., Cauda, R., Viscoli, C., & Viale, P. (2015). Infections caused by KPC-producing Klebsiella pneumoniae: differences in therapy and mortality in a multicentre study. Journal of Antimicrobial Chemotherapy, 70, 2133-2143. https://doi.org/10.1093/jac/dkv086

@article{3f48baeab1e24d6595ee44f8565f4bdd,

title = "Infections caused by KPC-producing Klebsiella pneumoniae: differences in therapy and mortality in a multicentre study",

abstract = "Infections caused by Klebsiella pneumoniae (Kp) carbapenemase (KPC)-producing strains of Kp have become a significant threat in recent years. To assess their outcomes and identify risk factors for 14 day mortality, we conducted a 4 year (2010-13) retrospective cohort study in five large Italian teaching hospitals.",

keywords = "carbapenem resistance, carbapenemases, colistin resistance, combination therapy, inadequate empirical therapy, meropenem MICs, treatment, carbapenem resistance, carbapenemases, colistin resistance, combination therapy, inadequate empirical therapy, meropenem MICs, treatment",

author = "Mario Tumbarello and Trecarichi, \{Enrico Maria\} and \{De Rosa\}, \{Francesco Giuseppe\} and Maddalena Giannella and Giacobbe, \{Daniele Roberto\} and Matteo Bassetti and Losito, \{Angela Raffaella\} and Michele Bartoletti and \{Del Bono\}, Valerio and Silvia Corcione and Giuseppe Maiuro and Sara Tedeschi and Luigi Celani and Cardellino, \{Chiara Simona\} and Teresa Spanu and Anna Marchese and Simone Ambretti and Roberto Cauda and Claudio Viscoli and Pierluigi Viale",

year = "2015",

doi = "10.1093/jac/dkv086",

language = "English",

volume = "70",

pages = "2133--2143",

journal = "Journal of Antimicrobial Chemotherapy",

issn = "1460-2091",

publisher = "Oxford University Press",

}

Tumbarello, M, Trecarichi, EM, De Rosa, FG, Giannella, M, Giacobbe, DR, Bassetti, M, Losito, AR, Bartoletti, M, Del Bono, V, Corcione, S, Maiuro, G, Tedeschi, S, Celani, L, Cardellino, CS, Spanu, T, Marchese, A, Ambretti, S, Cauda, R, Viscoli, C & Viale, P 2015, 'Infections caused by KPC-producing Klebsiella pneumoniae: differences in therapy and mortality in a multicentre study', Journal of Antimicrobial Chemotherapy, vol. 70, pagg. 2133-2143. https://doi.org/10.1093/jac/dkv086

TY - JOUR

T1 - Infections caused by KPC-producing Klebsiella pneumoniae: differences in therapy and mortality in a multicentre study

AU - Tumbarello, Mario

AU - Trecarichi, Enrico Maria

AU - De Rosa, Francesco Giuseppe

AU - Giannella, Maddalena

AU - Giacobbe, Daniele Roberto

AU - Bassetti, Matteo

AU - Losito, Angela Raffaella

AU - Bartoletti, Michele

AU - Del Bono, Valerio

AU - Corcione, Silvia

AU - Maiuro, Giuseppe

AU - Tedeschi, Sara

AU - Celani, Luigi

AU - Cardellino, Chiara Simona

AU - Spanu, Teresa

AU - Marchese, Anna

AU - Ambretti, Simone

AU - Cauda, Roberto

AU - Viscoli, Claudio

AU - Viale, Pierluigi

PY - 2015

Y1 - 2015

N2 - Infections caused by Klebsiella pneumoniae (Kp) carbapenemase (KPC)-producing strains of Kp have become a significant threat in recent years. To assess their outcomes and identify risk factors for 14 day mortality, we conducted a 4 year (2010-13) retrospective cohort study in five large Italian teaching hospitals.

AB - Infections caused by Klebsiella pneumoniae (Kp) carbapenemase (KPC)-producing strains of Kp have become a significant threat in recent years. To assess their outcomes and identify risk factors for 14 day mortality, we conducted a 4 year (2010-13) retrospective cohort study in five large Italian teaching hospitals.

KW - carbapenem resistance

KW - carbapenemases

KW - colistin resistance

KW - combination therapy

KW - inadequate empirical therapy

KW - meropenem MICs

KW - treatment

KW - carbapenem resistance

KW - carbapenemases

KW - colistin resistance

KW - combination therapy

KW - inadequate empirical therapy

KW - meropenem MICs

KW - treatment

UR - http://hdl.handle.net/10807/72202

U2 - 10.1093/jac/dkv086

DO - 10.1093/jac/dkv086

M3 - Article

SN - 1460-2091

VL - 70

SP - 2133

EP - 2143

JO - Journal of Antimicrobial Chemotherapy

JF - Journal of Antimicrobial Chemotherapy

ER -

Infections caused by KPC-producing Klebsiella pneumoniae: differences in therapy and mortality in a multicentre study

Abstract

Keywords

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