Infections caused by KPC-producing Klebsiella pneumoniae: differences in therapy and mortality in a multicentre study

Mario Tumbarello; Enrico Maria Trecarichi; Francesco Giuseppe De Rosa; Maddalena Giannella; Daniele Roberto Giacobbe; Matteo Bassetti; Angela Raffaella Losito; Michele Bartoletti; Valerio Del Bono; Silvia Corcione; Giuseppe Maiuro; Sara Tedeschi; Luigi Celani; Chiara Simona Cardellino; Teresa Spanu Pennestri; Anna Marchese; Simone Ambretti; Roberto Cauda; Claudio Viscoli; Pierluigi Viale

doi:10.1093/jac/dkv086

Infections caused by KPC-producing Klebsiella pneumoniae: differences in therapy and mortality in a multicentre study

Mario Tumbarello, Enrico Maria Trecarichi, Francesco Giuseppe De Rosa, Maddalena Giannella, Daniele Roberto Giacobbe, Matteo Bassetti, Angela Raffaella Losito, Michele Bartoletti, Valerio Del Bono, Silvia Corcione, Giuseppe Maiuro, Sara Tedeschi, Luigi Celani, Chiara Simona Cardellino, Teresa Spanu Pennestri, Anna Marchese, Simone Ambretti, Roberto Cauda, Claudio Viscoli, Pierluigi Viale

Risultato della ricerca: Contributo in rivista › Articolo

316 Citazioni (Scopus)

Abstract

Infections caused by Klebsiella pneumoniae (Kp) carbapenemase (KPC)-producing strains of Kp have become a significant threat in recent years. To assess their outcomes and identify risk factors for 14 day mortality, we conducted a 4 year (2010-13) retrospective cohort study in five large Italian teaching hospitals.

Lingua originale	Inglese
pagine (da-a)	2133-2143
Numero di pagine	11
Rivista	Journal of Antimicrobial Chemotherapy
Volume	70
DOI	https://doi.org/10.1093/jac/dkv086
Stato di pubblicazione	Pubblicato - 2015

Keywords

carbapenem resistance
carbapenemases
colistin resistance
combination therapy
inadequate empirical therapy
meropenem MICs
treatment

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10.1093/jac/dkv086

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Tumbarello, M., Trecarichi, E. M., De Rosa, F. G., Giannella, M., Giacobbe, D. R., Bassetti, M., Losito, A. R., Bartoletti, M., Del Bono, V., Corcione, S., Maiuro, G., Tedeschi, S., Celani, L., Cardellino, C. S., Spanu Pennestri, T., Marchese, A., Ambretti, S., Cauda, R., Viscoli, C., & Viale, P. (2015). Infections caused by KPC-producing Klebsiella pneumoniae: differences in therapy and mortality in a multicentre study. Journal of Antimicrobial Chemotherapy, 70, 2133-2143. https://doi.org/10.1093/jac/dkv086

@article{e77b1fd7dd59475c8a90c69860c38f42,

title = "Infections caused by KPC-producing Klebsiella pneumoniae: differences in therapy and mortality in a multicentre study",

abstract = "Infections caused by Klebsiella pneumoniae (Kp) carbapenemase (KPC)-producing strains of Kp have become a significant threat in recent years. To assess their outcomes and identify risk factors for 14 day mortality, we conducted a 4 year (2010-13) retrospective cohort study in five large Italian teaching hospitals.",

keywords = "carbapenem resistance, carbapenemases, colistin resistance, combination therapy, inadequate empirical therapy, meropenem MICs, treatment, carbapenem resistance, carbapenemases, colistin resistance, combination therapy, inadequate empirical therapy, meropenem MICs, treatment",

author = "Mario Tumbarello and Trecarichi, \{Enrico Maria\} and \{De Rosa\}, \{Francesco Giuseppe\} and Maddalena Giannella and Giacobbe, \{Daniele Roberto\} and Matteo Bassetti and Losito, \{Angela Raffaella\} and Michele Bartoletti and \{Del Bono\}, Valerio and Silvia Corcione and Giuseppe Maiuro and Sara Tedeschi and Luigi Celani and Cardellino, \{Chiara Simona\} and \{Spanu Pennestri\}, Teresa and Anna Marchese and Simone Ambretti and Roberto Cauda and Claudio Viscoli and Pierluigi Viale",

year = "2015",

doi = "10.1093/jac/dkv086",

language = "English",

volume = "70",

pages = "2133--2143",

journal = "Journal of Antimicrobial Chemotherapy",

issn = "0305-7453",

publisher = "Oxford University Press",

}

Tumbarello, M, Trecarichi, EM, De Rosa, FG, Giannella, M, Giacobbe, DR, Bassetti, M, Losito, AR, Bartoletti, M, Del Bono, V, Corcione, S, Maiuro, G, Tedeschi, S, Celani, L, Cardellino, CS, Spanu Pennestri, T, Marchese, A, Ambretti, S, Cauda, R, Viscoli, C & Viale, P 2015, 'Infections caused by KPC-producing Klebsiella pneumoniae: differences in therapy and mortality in a multicentre study', Journal of Antimicrobial Chemotherapy, vol. 70, pagg. 2133-2143. https://doi.org/10.1093/jac/dkv086

TY - JOUR

T1 - Infections caused by KPC-producing Klebsiella pneumoniae: differences in therapy and mortality in a multicentre study

AU - Tumbarello, Mario

AU - Trecarichi, Enrico Maria

AU - De Rosa, Francesco Giuseppe

AU - Giannella, Maddalena

AU - Giacobbe, Daniele Roberto

AU - Bassetti, Matteo

AU - Losito, Angela Raffaella

AU - Bartoletti, Michele

AU - Del Bono, Valerio

AU - Corcione, Silvia

AU - Maiuro, Giuseppe

AU - Tedeschi, Sara

AU - Celani, Luigi

AU - Cardellino, Chiara Simona

AU - Spanu Pennestri, Teresa

AU - Marchese, Anna

AU - Ambretti, Simone

AU - Cauda, Roberto

AU - Viscoli, Claudio

AU - Viale, Pierluigi

PY - 2015

Y1 - 2015

N2 - Infections caused by Klebsiella pneumoniae (Kp) carbapenemase (KPC)-producing strains of Kp have become a significant threat in recent years. To assess their outcomes and identify risk factors for 14 day mortality, we conducted a 4 year (2010-13) retrospective cohort study in five large Italian teaching hospitals.

AB - Infections caused by Klebsiella pneumoniae (Kp) carbapenemase (KPC)-producing strains of Kp have become a significant threat in recent years. To assess their outcomes and identify risk factors for 14 day mortality, we conducted a 4 year (2010-13) retrospective cohort study in five large Italian teaching hospitals.

KW - carbapenem resistance

KW - carbapenemases

KW - colistin resistance

KW - combination therapy

KW - inadequate empirical therapy

KW - meropenem MICs

KW - treatment

KW - carbapenem resistance

KW - carbapenemases

KW - colistin resistance

KW - combination therapy

KW - inadequate empirical therapy

KW - meropenem MICs

KW - treatment

UR - http://hdl.handle.net/10807/72246

U2 - 10.1093/jac/dkv086

DO - 10.1093/jac/dkv086

M3 - Article

SN - 0305-7453

VL - 70

SP - 2133

EP - 2143

JO - Journal of Antimicrobial Chemotherapy

JF - Journal of Antimicrobial Chemotherapy

ER -

Infections caused by KPC-producing Klebsiella pneumoniae: differences in therapy and mortality in a multicentre study

Abstract

Keywords

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