Induction of Ca2+ flux by adhesion molecules in lymphocytes

Integrins participate in numerous complex biological processes that include cell growth, differentiation, and migration, tissue organization and remodeling, inflammation, and immune response (1). Signals contributed by integrin-mediated cell adhesion cooperate with classical activatory receptors in initiating cellular activities, such as mitosis, secretion, or gene expression (2); by these means, cellular responses take into account all aspects of their environment.