Inducing tolerability of adverse events increases sorafenib exposure and optimizes patient's outcome in advanced hepatocellular carcinoma

Francesca Romana Ponziani; Antonio Gasbarrini

doi:10.1111/liv.13052

Inducing tolerability of adverse events increases sorafenib exposure and optimizes patient's outcome in advanced hepatocellular carcinoma

Francesca Romana Ponziani, Antonio Gasbarrini

Risultato della ricerca: Contributo in rivista › Articolo in rivista

16 Citazioni (Scopus)

Abstract

Various grades of adverse events are associated with sorafenib and have recently been considered as a surrogate of response in patients with advanced hepatocellular carcinoma. The aim of this prospective study was to measure the efficacy of a sorafenib dose reduction regimen, adjusted on patient's tolerability, and aimed at increasing the exposure to the drug.

Lingua originale	English
pagine (da-a)	N/A-N/A
Rivista	Liver International
DOI	https://doi.org/10.1111/liv.13052
Stato di pubblicazione	Pubblicato - 2015

Keywords

adverse events
hepatocellular carcinoma
sorafenib
tolerable adverse events protocol
toxicity
tumor response

Accesso al documento

10.1111/liv.13052

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abstract = "Various grades of adverse events are associated with sorafenib and have recently been considered as a surrogate of response in patients with advanced hepatocellular carcinoma. The aim of this prospective study was to measure the efficacy of a sorafenib dose reduction regimen, adjusted on patient's tolerability, and aimed at increasing the exposure to the drug.",

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AU - Ponziani, Francesca Romana

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KW - sorafenib

KW - tolerable adverse events protocol

KW - toxicity

KW - tumor response

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KW - hepatocellular carcinoma

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KW - tolerable adverse events protocol

KW - toxicity

KW - tumor response

UR - http://hdl.handle.net/10807/70768

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Inducing tolerability of adverse events increases sorafenib exposure and optimizes patient's outcome in advanced hepatocellular carcinoma

Abstract

Keywords

Accesso al documento

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