Indeterminate cell histiocytosis: a rare histiocytic disorder

L Manente, C Cotellessa, I Schmitt, Ketty Peris, G Torlone, Ao Muda, Mc Romano, S. Chementi

Risultato della ricerca: Contributo in rivistaArticolo in rivista

34 Citazioni (Scopus)


A 64-year-old woman, otherwise healthy, presented with multiple reddish-brown, slightly yellowish papules on the face and neck, which had developed 3 years earlier. The lesions were painless and nonpruritic and varied in diameter from 1 to 5 mm. Histological and immunohistochemical examination of cutaneous biopsies revealed a diffuse dermal infiltrate composed mainly of histiocytes which expressed both Langerhans cell as well as monocytic/macrophages cell marker characteristics. Electron microscopic studies revealed no Birbeck granules within the cytoplasm of the neoplastic cells, leading to a diagnosis of indeterminate cell histiocytosis. Indeterminate cell histiocytosis is a very rare disease characterized by the proliferation of indeterminate histiocytes which morphologically and immunophenotypically resemble Langerhans cells but lack Birbeck granules.
Lingua originaleEnglish
pagine (da-a)276-283
Numero di pagine8
RivistaAmerican Journal of Dermatopathology
Stato di pubblicazionePubblicato - 1997


  • Female
  • Histiocytosis
  • Humans
  • Middle Aged
  • Skin


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