Increased total antioxidant capacity in seminal plasma of varicocele patients: a multivariate analysis

Andrea Silvestrini, Alfredo Pontecorvi, Elisabetta Meucci, Domenico Milardi, Antonio Bianchi, Laura De Marinis Grasso, A Mancini, R Festa

Risultato della ricerca: Contributo in rivistaArticolo in rivista

12 Citazioni (Scopus)

Abstract

To investigate seminal antioxidant systems and their correlation with hormonal pattern in varicocele patients, we studied 33 varicocele (VAR) patients (12 oligozoospermic, 21 normozoospermic) and 34 non-VARs (10 idiopathic oligozoospermic, 24 normozoospermic). Non-enzymatic total antioxidant capacity (TAC) was measured using H(2)O(2)-metamyoglobin, which generates the radical form, spectroscopically detectable, of the chromogen 2,2',-azinobis-3-ethylbenzothiazoline-6-sulphonate (ABTS): time till appearance (Lag) of ABTS*(-) signifies antioxidant concentration. Lag was significantly longer in VARs than controls suggesting ineffective utilization of antioxidants. A significant direct correlation (r = 0.65, p < 0.01) of Lag with sperm count was observed in non-VARs, while in VARs it was inverted, as well as with hematic FSH levels. A multivariate analysis including FSH, Lag, progressive spermatozoa, oligozoospermia and varicocele indicated a strong inverse correlation between FSH and motility (r(2) = 0.31, p > F = 0.0007), not modified by Lag (r(2) = 0.31, p > F = 0.002). Their inverse correlation with Lag may suggest that higher FSH levels, improving sperm antioxidant efficiency, counterbalance varicocele-induced dyspermia.
Lingua originaleEnglish
pagine (da-a)37-42
Numero di pagine6
RivistaArchives of Andrology
Volume53
DOI
Stato di pubblicazionePubblicato - 2007

Keywords

  • Adult
  • Antioxidants
  • Humans
  • Male
  • Multivariate Analysis
  • Oligospermia
  • Reference Values
  • Semen
  • Sperm Count
  • Varicocele

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