Increased PTPN22 Expression and Defective CREB Activation Impair Regulatory T-Cell Differentiation in Non-ST-Segment Elevation Acute Coronary Syndromes

Luigi Marzio Biasucci; Giovanna Liuzzo; Filippo Crea; Davide Flego; Anna Severino; Francesco Trotta; Sarassunta Ucci; Chiara Zara; Daniela Pedicino

doi:10.1016/j.jacc.2015.01.027

Increased PTPN22 Expression and Defective CREB Activation Impair Regulatory T-Cell Differentiation in Non-ST-Segment Elevation Acute Coronary Syndromes

Luigi Marzio Biasucci, Giovanna Liuzzo, Filippo Crea, Davide Flego, Anna Severino, Francesco Trotta, Sarassunta Ucci, Chiara Zara, Daniela Pedicino

Risultato della ricerca: Contributo in rivista › Articolo in rivista

23 Citazioni (Scopus)

Abstract

Critical impairment of adaptive immune response has been observed in patients with acute coronary syndromes (ACS) with reduced expansion of regulatory T cells (Treg) and enhanced effector T-cell responsiveness, both associated with poorer outcomes.

Lingua originale	English
pagine (da-a)	1175-1186
Numero di pagine	12
Rivista	JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
Volume	65
DOI	https://doi.org/10.1016/j.jacc.2015.01.027
Stato di pubblicazione	Pubblicato - 2015

Keywords

dysregulation
immune system
signaling pathway

Accesso al documento

10.1016/j.jacc.2015.01.027

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Cita questo

Biasucci, L. M., Liuzzo, G., Crea, F., Flego, D., Severino, A., Trotta, F., Ucci, S., Zara, C., & Pedicino, D. (2015). Increased PTPN22 Expression and Defective CREB Activation Impair Regulatory T-Cell Differentiation in Non-ST-Segment Elevation Acute Coronary Syndromes. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 65, 1175-1186. https://doi.org/10.1016/j.jacc.2015.01.027

Biasucci, Luigi Marzio ; Liuzzo, Giovanna ; Crea, Filippo ; Flego, Davide ; Severino, Anna ; Trotta, Francesco ; Ucci, Sarassunta ; Zara, Chiara ; Pedicino, Daniela. / Increased PTPN22 Expression and Defective CREB Activation Impair Regulatory T-Cell Differentiation in Non-ST-Segment Elevation Acute Coronary Syndromes. In: JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. 2015 ; Vol. 65. pagg. 1175-1186.

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title = "Increased PTPN22 Expression and Defective CREB Activation Impair Regulatory T-Cell Differentiation in Non-ST-Segment Elevation Acute Coronary Syndromes",

abstract = "Critical impairment of adaptive immune response has been observed in patients with acute coronary syndromes (ACS) with reduced expansion of regulatory T cells (Treg) and enhanced effector T-cell responsiveness, both associated with poorer outcomes.",

keywords = "dysregulation, immune system, signaling pathway, dysregulation, immune system, signaling pathway",

author = "Biasucci, {Luigi Marzio} and Giovanna Liuzzo and Filippo Crea and Davide Flego and Anna Severino and Francesco Trotta and Sarassunta Ucci and Chiara Zara and Daniela Pedicino",

year = "2015",

doi = "10.1016/j.jacc.2015.01.027",

language = "English",

volume = "65",

pages = "1175--1186",

journal = "JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY",

issn = "0735-1097",

publisher = "Attuale:ELSEVIER SCIENCE INC, 360 PARK AVE SOUTH, NEW YORK, USA, NY, 10010-1710 W B Saunders Company:Fulfillment Department, The Curtis Center, Independence Square West:Philadelphia, PA 19106:(800)654-2452, (215)238-7800, EMAIL: wbspcs@harcourt.com, INTERNET: http://elsevierhealth.com, Fax: (215)238-6445",

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Biasucci, LM , Liuzzo, G , Crea, F, Flego, D, Severino, A, Trotta, F, Ucci, S, Zara, C & Pedicino, D 2015, 'Increased PTPN22 Expression and Defective CREB Activation Impair Regulatory T-Cell Differentiation in Non-ST-Segment Elevation Acute Coronary Syndromes', JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, vol. 65, pagg. 1175-1186. https://doi.org/10.1016/j.jacc.2015.01.027

Increased PTPN22 Expression and Defective CREB Activation Impair Regulatory T-Cell Differentiation in Non-ST-Segment Elevation Acute Coronary Syndromes. / Biasucci, Luigi Marzio ; Liuzzo, Giovanna ; Crea, Filippo; Flego, Davide; Severino, Anna; Trotta, Francesco; Ucci, Sarassunta; Zara, Chiara; Pedicino, Daniela.

In: JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol. 65, 2015, pag. 1175-1186.

Risultato della ricerca: Contributo in rivista › Articolo in rivista

TY - JOUR

T1 - Increased PTPN22 Expression and Defective CREB Activation Impair Regulatory T-Cell Differentiation in Non-ST-Segment Elevation Acute Coronary Syndromes

AU - Biasucci, Luigi Marzio

AU - Liuzzo, Giovanna

AU - Crea, Filippo

AU - Flego, Davide

AU - Severino, Anna

AU - Trotta, Francesco

AU - Ucci, Sarassunta

AU - Zara, Chiara

AU - Pedicino, Daniela

PY - 2015

Y1 - 2015

N2 - Critical impairment of adaptive immune response has been observed in patients with acute coronary syndromes (ACS) with reduced expansion of regulatory T cells (Treg) and enhanced effector T-cell responsiveness, both associated with poorer outcomes.

AB - Critical impairment of adaptive immune response has been observed in patients with acute coronary syndromes (ACS) with reduced expansion of regulatory T cells (Treg) and enhanced effector T-cell responsiveness, both associated with poorer outcomes.

KW - dysregulation

KW - immune system

KW - signaling pathway

KW - dysregulation

KW - immune system

KW - signaling pathway

UR - http://hdl.handle.net/10807/66135

U2 - 10.1016/j.jacc.2015.01.027

DO - 10.1016/j.jacc.2015.01.027

M3 - Article

VL - 65

SP - 1175

EP - 1186

JO - JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

JF - JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

SN - 0735-1097

ER -