Increased PTPN22 Expression and Defective CREB Activation Impair Regulatory T-Cell Differentiation in Non-ST-Segment Elevation Acute Coronary Syndromes

Luigi Marzio Biasucci, Giovanna Liuzzo, Filippo Crea, Davide Flego, Anna Severino, Francesco Trotta, Sarassunta Ucci, Chiara Zara, Daniela Pedicino

Risultato della ricerca: Contributo in rivistaArticolo in rivista

23 Citazioni (Scopus)

Abstract

Critical impairment of adaptive immune response has been observed in patients with acute coronary syndromes (ACS) with reduced expansion of regulatory T cells (Treg) and enhanced effector T-cell responsiveness, both associated with poorer outcomes.
Lingua originaleEnglish
pagine (da-a)1175-1186
Numero di pagine12
RivistaJOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
Volume65
DOI
Stato di pubblicazionePubblicato - 2015

Keywords

  • dysregulation
  • immune system
  • signaling pathway

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