Increased polymorphonuclear leukocyte Fc gamma-dependent chemiluminescence in active psoriasis is not related to FcRIII (CD16) receptor expression

Clara De Simone, Cristina Guerriero, Antonio Venier, Carlo Rumi, Pasquale De Sole, S Bussa, R Fresu

Risultato della ricerca: Contributo in rivistaArticolo in rivista

1 Citazioni (Scopus)

Abstract

The role of the two main serum opsonins (IgG and C3b) in the induction of polymorphonuclear leukocyte chemiluminescence was studied in a group of psoriatic patients. Chemiluminescence was stimulated with zymosan opsonized by fresh plasma (IgG- and C3b-dependent chemiluminescence) or by complement-depleted plasma (IgG-dependent chemiluminescence). While C3b-dependent chemiluminescence was similar in patients with chronic or active forms of psoriasis, IgG-dependent chemiluminescence was significantly increased in patients with active disease. However, FcR-III expression, evaluated by means of flow cytofluorimetry, was similar in the different groups of patients studied. The discrepancy between Fc-receptor (CD16) expression and IgG-dependent chemiluminescence is, therefore, indicative of modifications that occur in psoriatic neutrophils that do not involve FcIII-receptor expression.
Lingua originaleEnglish
pagine (da-a)89-91
Numero di pagine3
RivistaExperimental Dermatology
Volume2
Stato di pubblicazionePubblicato - 1993

Keywords

  • Adult
  • Aged
  • Complement C3b
  • Female
  • Humans
  • Immunoglobulin Fc Fragments
  • Immunoglobulin G
  • Luminescent Measurements
  • Male
  • Middle Aged
  • Neutrophils
  • Opsonin Proteins
  • Psoriasis
  • Receptors, Complement 3b
  • Receptors, IgG
  • Respiratory Burst
  • Zymosan

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