Increased forensic efficiency of a STR-based Y-specific haplotype by addition of the highly polymorphic DYS385 locus

Vincenzo Lorenzo Pascali; Marina Dobosz; Ilaria Boschi; Ernesto D'Aloja; A Caglià

Increased forensic efficiency of a STR-based Y-specific haplotype by addition of the highly polymorphic DYS385 locus

Vincenzo Lorenzo Pascali, Marina Dobosz, Ilaria Boschi, Ernesto D'Aloja, A Caglià

Risultato della ricerca: Contributo in rivista › Articolo in rivista

Abstract

The polymorphic short tandem repeat (STR) locus DYS385 mapping to the male-specific region of human Y chromosome, was used to reinvestigate 125 unrelated Italian males, from our data archive, who had been previously typed for 7 different Y-specific STRs (DYS19, DYS389 I and II, DYS390, DYS391, DYS392, DYS393), defining a haplotype now widely adopted in the forensic context. The aim of this study was to improve the information value of the original haplotype in view of its application to issues of personal identification and parental analysis. DYS385 proved to be highly polymorphic (94.5% gene diversity) and the overall individualization capacity of the 8-loci haplotype was raised to 93.6%, with 117 unique assets out of 125 tested samples.

Lingua originale	English
pagine (da-a)	142-146
Numero di pagine	5
Rivista	International Journal of Legal Medicine
Volume	111
Stato di pubblicazione	Pubblicato - 1998

Keywords

DYS385
Short tandem repeats
Y-chromosome
Y-haplotype

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title = "Increased forensic efficiency of a STR-based Y-specific haplotype by addition of the highly polymorphic DYS385 locus",

abstract = "The polymorphic short tandem repeat (STR) locus DYS385 mapping to the male-specific region of human Y chromosome, was used to reinvestigate 125 unrelated Italian males, from our data archive, who had been previously typed for 7 different Y-specific STRs (DYS19, DYS389 I and II, DYS390, DYS391, DYS392, DYS393), defining a haplotype now widely adopted in the forensic context. The aim of this study was to improve the information value of the original haplotype in view of its application to issues of personal identification and parental analysis. DYS385 proved to be highly polymorphic (94.5% gene diversity) and the overall individualization capacity of the 8-loci haplotype was raised to 93.6%, with 117 unique assets out of 125 tested samples.",

keywords = "DYS385, Short tandem repeats, Y-chromosome, Y-haplotype, DYS385, Short tandem repeats, Y-chromosome, Y-haplotype",

author = "Pascali, {Vincenzo Lorenzo} and Marina Dobosz and Ilaria Boschi and Ernesto D'Aloja and A Cagli{\`a}",

year = "1998",

language = "English",

volume = "111",

pages = "142--146",

journal = "International Journal of Legal Medicine",

issn = "0937-9827",

publisher = "Springer Verlag Germany:Tiergartenstrasse 17, D 69121 Heidelberg Germany:011 49 6221 3450, EMAIL: g.braun@springer.de, INTERNET: http://www.springer.de, Fax: 011 49 6221 345229",

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TY - JOUR

T1 - Increased forensic efficiency of a STR-based Y-specific haplotype by addition of the highly polymorphic DYS385 locus

AU - Pascali, Vincenzo Lorenzo

AU - Dobosz, Marina

AU - Boschi, Ilaria

AU - D'Aloja, Ernesto

AU - Caglià, A

PY - 1998

Y1 - 1998

N2 - The polymorphic short tandem repeat (STR) locus DYS385 mapping to the male-specific region of human Y chromosome, was used to reinvestigate 125 unrelated Italian males, from our data archive, who had been previously typed for 7 different Y-specific STRs (DYS19, DYS389 I and II, DYS390, DYS391, DYS392, DYS393), defining a haplotype now widely adopted in the forensic context. The aim of this study was to improve the information value of the original haplotype in view of its application to issues of personal identification and parental analysis. DYS385 proved to be highly polymorphic (94.5% gene diversity) and the overall individualization capacity of the 8-loci haplotype was raised to 93.6%, with 117 unique assets out of 125 tested samples.

AB - The polymorphic short tandem repeat (STR) locus DYS385 mapping to the male-specific region of human Y chromosome, was used to reinvestigate 125 unrelated Italian males, from our data archive, who had been previously typed for 7 different Y-specific STRs (DYS19, DYS389 I and II, DYS390, DYS391, DYS392, DYS393), defining a haplotype now widely adopted in the forensic context. The aim of this study was to improve the information value of the original haplotype in view of its application to issues of personal identification and parental analysis. DYS385 proved to be highly polymorphic (94.5% gene diversity) and the overall individualization capacity of the 8-loci haplotype was raised to 93.6%, with 117 unique assets out of 125 tested samples.

KW - DYS385

KW - Short tandem repeats

KW - Y-chromosome

KW - Y-haplotype

KW - DYS385

KW - Short tandem repeats

KW - Y-chromosome

KW - Y-haplotype

UR - http://hdl.handle.net/10807/10894

M3 - Article

VL - 111

SP - 142

EP - 146

JO - International Journal of Legal Medicine

JF - International Journal of Legal Medicine

SN - 0937-9827

ER -