TY - JOUR
T1 - Increased forensic efficiency of a STR-based Y-specific haplotype by addition of the highly polymorphic DYS385 locus
AU - Caglià, A
AU - Dobosz, Marina
AU - Boschi, Ilaria
AU - D'Aloja, Ernesto
AU - Pascali, Vincenzo Lorenzo
PY - 1998
Y1 - 1998
N2 - The polymorphic short tandem repeat (STR) locus DYS385 mapping to the male-specific region of human Y chromosome, was used to reinvestigate 125 unrelated Italian males, from our data archive, who had been previously typed for 7 different Y-specific STRs (DYS19, DYS389 I and II, DYS390, DYS391, DYS392, DYS393), defining a haplotype now widely adopted in the forensic context. The aim of this study was to improve the information value of the original haplotype in view of its application to issues of personal identification and parental analysis. DYS385 proved to be highly polymorphic (94.5% gene diversity) and the overall individualization capacity of the 8-loci haplotype was raised to 93.6%, with 117 unique assets out of 125 tested samples.
AB - The polymorphic short tandem repeat (STR) locus DYS385 mapping to the male-specific region of human Y chromosome, was used to reinvestigate 125 unrelated Italian males, from our data archive, who had been previously typed for 7 different Y-specific STRs (DYS19, DYS389 I and II, DYS390, DYS391, DYS392, DYS393), defining a haplotype now widely adopted in the forensic context. The aim of this study was to improve the information value of the original haplotype in view of its application to issues of personal identification and parental analysis. DYS385 proved to be highly polymorphic (94.5% gene diversity) and the overall individualization capacity of the 8-loci haplotype was raised to 93.6%, with 117 unique assets out of 125 tested samples.
KW - DYS385
KW - Short tandem repeats
KW - Y-chromosome
KW - Y-haplotype
KW - DYS385
KW - Short tandem repeats
KW - Y-chromosome
KW - Y-haplotype
UR - http://hdl.handle.net/10807/10894
M3 - Article
SN - 0937-9827
VL - 111
SP - 142
EP - 146
JO - International Journal of Legal Medicine
JF - International Journal of Legal Medicine
ER -