TY - JOUR
T1 - Increased fibulin-1 plasma levels in polycystic ovary syndrome (PCOS) patients: possible contribution to the link between PCOS and cardiovascular risk
AU - Scarinci, Elisa
AU - Tropea, Anna
AU - Russo, Giulio
AU - Notaristefano, Giovanna
AU - Messana, C.
AU - Alesiani, O.
AU - Fabozzi, Simone Michele
AU - Lanzone, Antonio
AU - Apa, Rosanna
PY - 2019
Y1 - 2019
N2 - Purpose: To investigate a possible relation between fibulin-1 plasma levels and PCOS. Design: ELISA quantitative determination of human fibulin-1. Methods: 50 women with PCOS and 40 control patients who attended the Unit of Human Reproductive Pathophysiology, Università Cattolica del Sacro Cuore, Rome, were enrolled. Ultrasonographic pelvic examinations, hormonal profile assays, oral tolerance test OGTT, lipid profile and ELISA quantitative determination of human fibulin-1 were performed. Results: Fibulin-1 levels were found to be statistically significantly higher in PCOS patients than in matched control women. No statistically significant positive correlation was found between fibulin-1 and AUCi, HOMA-IR, total cholesterol, LDL, AMH, androstenedione and FAI, whereas a statistically significant positive correlation was found between fibulin-1 and 17OHP (p = 0.016) in the PCOS group. However, multivariable linear regression analysis showed that 17 OH P did not independently predict fibulin-1 levels (p = 0.089). Conclusions: Our data could contribute to explain the hypothesized increased cardiovascular risk and vascular damage in patients with PCOS. A better understanding of the cellular and molecular mechanisms involved in cardiometabolic disorders associated with PCOS is mandatory to identify new therapeutic strategies to eventually prevent the progression of cardiovascular diseases in these patients.
AB - Purpose: To investigate a possible relation between fibulin-1 plasma levels and PCOS. Design: ELISA quantitative determination of human fibulin-1. Methods: 50 women with PCOS and 40 control patients who attended the Unit of Human Reproductive Pathophysiology, Università Cattolica del Sacro Cuore, Rome, were enrolled. Ultrasonographic pelvic examinations, hormonal profile assays, oral tolerance test OGTT, lipid profile and ELISA quantitative determination of human fibulin-1 were performed. Results: Fibulin-1 levels were found to be statistically significantly higher in PCOS patients than in matched control women. No statistically significant positive correlation was found between fibulin-1 and AUCi, HOMA-IR, total cholesterol, LDL, AMH, androstenedione and FAI, whereas a statistically significant positive correlation was found between fibulin-1 and 17OHP (p = 0.016) in the PCOS group. However, multivariable linear regression analysis showed that 17 OH P did not independently predict fibulin-1 levels (p = 0.089). Conclusions: Our data could contribute to explain the hypothesized increased cardiovascular risk and vascular damage in patients with PCOS. A better understanding of the cellular and molecular mechanisms involved in cardiometabolic disorders associated with PCOS is mandatory to identify new therapeutic strategies to eventually prevent the progression of cardiovascular diseases in these patients.
KW - Adult
KW - Biomarkers
KW - Calcium-Binding Proteins
KW - Cardiovascular Diseases
KW - Cardiovascular risk
KW - Endocrinology
KW - Endocrinology, Diabetes and Metabolism
KW - Female
KW - Fibulin-1
KW - Hormonal assay
KW - Humans
KW - PCOS
KW - Polycystic Ovary Syndrome
KW - Risk Factors
KW - Young Adult
KW - Adult
KW - Biomarkers
KW - Calcium-Binding Proteins
KW - Cardiovascular Diseases
KW - Cardiovascular risk
KW - Endocrinology
KW - Endocrinology, Diabetes and Metabolism
KW - Female
KW - Fibulin-1
KW - Hormonal assay
KW - Humans
KW - PCOS
KW - Polycystic Ovary Syndrome
KW - Risk Factors
KW - Young Adult
UR - http://hdl.handle.net/10807/134426
UR - http://link.springer.com/journal/40618
U2 - 10.1007/s40618-018-0891-3
DO - 10.1007/s40618-018-0891-3
M3 - Article
SN - 0391-4097
VL - 42
SP - 91
EP - 96
JO - Journal of Endocrinological Investigation
JF - Journal of Endocrinological Investigation
ER -