TY - JOUR
T1 - Increased expression of T-bet in circulating B cells from a patient with multiple sclerosis and celiac disease
AU - Frisullo, Giovanni
AU - Nociti, Viviana
AU - Iorio, Raffaele
AU - Patanella, Agata Katia
AU - Marti, Alessandro
AU - Cammarota, Giovanni
AU - Mirabella, Massimiliano
AU - Batocchi, Anna Paola
PY - 2008
Y1 - 2008
N2 - Multiple sclerosis (MS) and celiac disease (CD) are considered to be T-cell-mediated autoimmune diseases. We describe a woman affected by a relapsing-remitting demyelinating disease of the central nervous system and occult CD (MS-CD), who showed during neurologic exacerbations a strong increased expression of T-bet, the key transcription factor for the development of Th1 cells, in circulating T, B cells and monocytes. Conversely, no difference of T-bet expression was observed in B cells from relapsing-remitting MS patients, either in relapse or in remission, and in controls. In the MS-CD patient, the interaction between MS- and CD-related inflammatory processes may result in an amplification of Th1 immune response
AB - Multiple sclerosis (MS) and celiac disease (CD) are considered to be T-cell-mediated autoimmune diseases. We describe a woman affected by a relapsing-remitting demyelinating disease of the central nervous system and occult CD (MS-CD), who showed during neurologic exacerbations a strong increased expression of T-bet, the key transcription factor for the development of Th1 cells, in circulating T, B cells and monocytes. Conversely, no difference of T-bet expression was observed in B cells from relapsing-remitting MS patients, either in relapse or in remission, and in controls. In the MS-CD patient, the interaction between MS- and CD-related inflammatory processes may result in an amplification of Th1 immune response
KW - celiac disease
KW - multiple sclerosis
KW - celiac disease
KW - multiple sclerosis
UR - http://hdl.handle.net/10807/19448
U2 - 10.1016/j.humimm.2008.09.008
DO - 10.1016/j.humimm.2008.09.008
M3 - Article
SN - 0198-8859
VL - 69
SP - 837
EP - 839
JO - Human Immunology
JF - Human Immunology
ER -