Increased expression of T-bet in circulating B cells from a patient with multiple sclerosis and celiac disease

Giovanni Cammarota, Massimiliano Mirabella, Giovanni Frisullo, Viviana Nociti, Raffaele Iorio, Agata Katia Patanella, Alessandro Marti, Anna Paola Batocchi, Pietro Attilio Tonali

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

14 Citazioni (Scopus)

Abstract

Multiple sclerosis (MS) and celiac disease (CD) are considered to be T-cell-mediated autoimmune diseases. We describe a woman affected by a relapsing-remitting demyelinating disease of the central nervous system and occult CD (MS-CD), who showed during neurologic exacerbations a strong increased expression of T-bet, the key transcription factor for the development of Th1 cells, in circulating T, B cells and monocytes. Conversely, no difference of T-bet expression was observed in B cells from relapsing-remitting MS patients, either in relapse or in remission, and in controls. In the MS-CD patient, the interaction between MS- and CD-related inflammatory processes may result in an amplification of Th1 immune response
Lingua originaleEnglish
pagine (da-a)837-839
Numero di pagine3
RivistaHuman Immunology
Stato di pubblicazionePubblicato - 2008

Keywords

  • celiac disease
  • multiple sclerosis

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