Increased Circulating Levels of Interleukin-6 Induce Perturbation in Redox-Regulated Signaling Cascades in Muscle of Dystrophic Mice

Bianca Maria Scicchitano, Laura Pelosi, Laura Forcina, Carmine Nicoletti, Antonio Musarò

Risultato della ricerca: Contributo in rivistaArticolo in rivista

10 Citazioni (Scopus)

Abstract

Duchenne muscular dystrophy (DMD) is an X-linked genetic disease in which dystrophin gene is mutated, resulting in dysfunctional or absent dystrophin protein. The pathology of dystrophic muscle includes degeneration, necrosis with inflammatory cell invasion, regeneration, and fibrous and fatty changes. Nevertheless, the mechanisms by which the absence of dystrophin leads to muscle degeneration remain to be fully elucidated. An imbalance between oxidant and antioxidant systems has been proposed as a secondary effect of DMD. However, the significance and precise extent of the perturbation in redox signaling cascades is poorly understood. We report that mdx dystrophic mice are able to activate a compensatory antioxidant response at the presymptomatic stage of the disease. In contrast, increased circulating levels of IL-6 perturb the redox signaling cascade, even prior to the necrotic stage, leading to severe features and progressive nature of muscular dystrophy.
Lingua originaleEnglish
pagine (da-a)1-10
Numero di pagine10
RivistaOxidative Medicine and Cellular Longevity
Volume2017
DOI
Stato di pubblicazionePubblicato - 2017

Keywords

  • Animals
  • Diaphragm
  • Disease Models, Animal
  • Disease Progression
  • Gene Expression Regulation
  • Interleukin-6
  • Mice, Inbred C57BL
  • Mice, Inbred mdx
  • Muscle, Skeletal
  • Muscular Dystrophy, Animal
  • NF-E2-Related Factor 2
  • Necrosis
  • Oxidation-Reduction
  • Reactive Oxygen Species
  • Signal Transduction
  • Time Factors

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