Increased CD95 (Fas) and PD-1 expression in peripheral blood T lymphocytes in COVID-19 patients

Elisabetta Metafuni; Stefan Hohaus; E. Maiolo; F. Marchionni; S. D'Innocenzo; Sorda M. La; M. Ferraironi; Francesco Ramundo; M. Fantoni; Rita Murri; Antonella Cingolani; Simona Sica; Antonio Gasbarrini; Maurizio Sanguinetti; Patrizia Chiusolo; Valerio De Stefano

doi:10.1111/bjh.17034

Increased CD95 (Fas) and PD-1 expression in peripheral blood T lymphocytes in COVID-19 patients

Elisabetta Metafuni
, Stefan Hohaus
, E. Maiolo
, F. Marchionni
, S. D'Innocenzo
, Sorda M. La
, M. Ferraironi
, Francesco Ramundo
, M. Fantoni
, Rita Murri
, Antonella Cingolani
, Simona Sica
, Antonio Gasbarrini
, Maurizio Sanguinetti
, Patrizia Chiusolo
, Valerio De Stefano

Risultato della ricerca: Contributo in rivista › Articolo

13 Citazioni (Scopus)

Abstract

A low count of CD4+ and CD8+ lymphocytes is a hallmark laboratory finding in the coronavirus disease 2019 (COVID-19). Using flow cytometry, we observed significantly higher CD95 (Fas) and PD-1 expression on both CD4+ T and CD8+ T cells in 42 COVID-19 patients when compared to controls. Higher CD95 expression in CD4+ cells correlated with lower CD4+ counts. A higher expression of CD95 in CD4+ and CD8+ lymphocytes correlated with a lower percentage of naive events. Our results might suggest a shift to antigen-activated T cells, expressing molecules increasing their propensity to apoptosis and exhaustion during COVID-19 infection.

Lingua originale	Inglese
pagine (da-a)	207-211
Numero di pagine	5
Rivista	British Journal of Haematology
Volume	191
Numero di pubblicazione	2
DOI	https://doi.org/10.1111/bjh.17034
Stato di pubblicazione	Pubblicato - 2020

All Science Journal Classification (ASJC) codes

Ematologia

Keywords

80 and over
Adult
Aged
Aging
Apoptosis
CD4-Positive T-Lymphocytes
CD8-Positive T-Lymphocytes
CD95 (Fas)
COVID-19
Female
Humans
Lymphocyte Count
Lymphocyte Subsets
Lymphopenia
Male
Middle Aged
PD-1
Prognosis
Programmed Cell Death 1 Receptor
SARS-CoV-2
apoptosis
exhaustion
fas Receptor

Accesso al documento

10.1111/bjh.17034

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Metafuni, E., Hohaus, S., Maiolo, E., Marchionni, F., D'Innocenzo, S., La, S. M., Ferraironi, M., Ramundo, F., Fantoni, M., Murri, R., Cingolani, A., Sica, S., Gasbarrini, A., Sanguinetti, M., Chiusolo, P., & De Stefano, V. (2020). Increased CD95 (Fas) and PD-1 expression in peripheral blood T lymphocytes in COVID-19 patients. British Journal of Haematology, 191(2), 207-211. https://doi.org/10.1111/bjh.17034

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abstract = "A low count of CD4+ and CD8+ lymphocytes is a hallmark laboratory finding in the coronavirus disease 2019 (COVID-19). Using flow cytometry, we observed significantly higher CD95 (Fas) and PD-1 expression on both CD4+ T and CD8+ T cells in 42 COVID-19 patients when compared to controls. Higher CD95 expression in CD4+ cells correlated with lower CD4+ counts. A higher expression of CD95 in CD4+ and CD8+ lymphocytes correlated with a lower percentage of naive events. Our results might suggest a shift to antigen-activated T cells, expressing molecules increasing their propensity to apoptosis and exhaustion during COVID-19 infection.",

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author = "Elisabetta Metafuni and Stefan Hohaus and E. Maiolo and F. Marchionni and S. D'Innocenzo and La, \{Sorda M.\} and M. Ferraironi and Francesco Ramundo and M. Fantoni and Rita Murri and Antonella Cingolani and Simona Sica and Antonio Gasbarrini and Maurizio Sanguinetti and Patrizia Chiusolo and \{De Stefano\}, Valerio",

year = "2020",

doi = "10.1111/bjh.17034",

language = "English",

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Metafuni, E, Hohaus, S, Maiolo, E, Marchionni, F, D'Innocenzo, S, La, SM, Ferraironi, M, Ramundo, F, Fantoni, M, Murri, R , Cingolani, A , Sica, S , Gasbarrini, A , Sanguinetti, M , Chiusolo, P & De Stefano, V 2020, 'Increased CD95 (Fas) and PD-1 expression in peripheral blood T lymphocytes in COVID-19 patients', British Journal of Haematology, vol. 191, n. 2, pagg. 207-211. https://doi.org/10.1111/bjh.17034

TY - JOUR

T1 - Increased CD95 (Fas) and PD-1 expression in peripheral blood T lymphocytes in COVID-19 patients

AU - Metafuni, Elisabetta

AU - Hohaus, Stefan

AU - Maiolo, E.

AU - Marchionni, F.

AU - D'Innocenzo, S.

AU - La, Sorda M.

AU - Ferraironi, M.

AU - Ramundo, Francesco

AU - Fantoni, M.

AU - Murri, Rita

AU - Cingolani, Antonella

AU - Sica, Simona

AU - Gasbarrini, Antonio

AU - Sanguinetti, Maurizio

AU - Chiusolo, Patrizia

AU - De Stefano, Valerio

PY - 2020

Y1 - 2020

N2 - A low count of CD4+ and CD8+ lymphocytes is a hallmark laboratory finding in the coronavirus disease 2019 (COVID-19). Using flow cytometry, we observed significantly higher CD95 (Fas) and PD-1 expression on both CD4+ T and CD8+ T cells in 42 COVID-19 patients when compared to controls. Higher CD95 expression in CD4+ cells correlated with lower CD4+ counts. A higher expression of CD95 in CD4+ and CD8+ lymphocytes correlated with a lower percentage of naive events. Our results might suggest a shift to antigen-activated T cells, expressing molecules increasing their propensity to apoptosis and exhaustion during COVID-19 infection.

AB - A low count of CD4+ and CD8+ lymphocytes is a hallmark laboratory finding in the coronavirus disease 2019 (COVID-19). Using flow cytometry, we observed significantly higher CD95 (Fas) and PD-1 expression on both CD4+ T and CD8+ T cells in 42 COVID-19 patients when compared to controls. Higher CD95 expression in CD4+ cells correlated with lower CD4+ counts. A higher expression of CD95 in CD4+ and CD8+ lymphocytes correlated with a lower percentage of naive events. Our results might suggest a shift to antigen-activated T cells, expressing molecules increasing their propensity to apoptosis and exhaustion during COVID-19 infection.

KW - 80 and over

KW - Adult

KW - Aged

KW - Aging

KW - Apoptosis

KW - CD4-Positive T-Lymphocytes

KW - CD8-Positive T-Lymphocytes

KW - CD95 (Fas)

KW - COVID-19

KW - Female

KW - Humans

KW - Lymphocyte Count

KW - Lymphocyte Subsets

KW - Lymphopenia

KW - Male

KW - Middle Aged

KW - PD-1

KW - Prognosis

KW - Programmed Cell Death 1 Receptor

KW - SARS-CoV-2

KW - apoptosis

KW - exhaustion

KW - fas Receptor

KW - 80 and over

KW - Adult

KW - Aged

KW - Aging

KW - Apoptosis

KW - CD4-Positive T-Lymphocytes

KW - CD8-Positive T-Lymphocytes

KW - CD95 (Fas)

KW - COVID-19

KW - Female

KW - Humans

KW - Lymphocyte Count

KW - Lymphocyte Subsets

KW - Lymphopenia

KW - Male

KW - Middle Aged

KW - PD-1

KW - Prognosis

KW - Programmed Cell Death 1 Receptor

KW - SARS-CoV-2

KW - apoptosis

KW - exhaustion

KW - fas Receptor

UR - https://publicatt.unicatt.it/handle/10807/166626

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U2 - 10.1111/bjh.17034

DO - 10.1111/bjh.17034

M3 - Article

SN - 0007-1048

VL - 191

SP - 207

EP - 211

JO - British Journal of Haematology

JF - British Journal of Haematology

IS - 2

ER -

Increased CD95 (Fas) and PD-1 expression in peripheral blood T lymphocytes in COVID-19 patients

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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