@article{5dd9ce11911f4fabb0bb6784c62a8c24,
title = "Increased CD95 (Fas) and PD-1 expression in peripheral blood T lymphocytes in COVID-19 patients",
abstract = "A low count of CD4+ and CD8+ lymphocytes is a hallmark laboratory finding in the coronavirus disease 2019 (COVID-19). Using flow cytometry, we observed significantly higher CD95 (Fas) and PD-1 expression on both CD4+ T and CD8+ T cells in 42 COVID-19 patients when compared to controls. Higher CD95 expression in CD4+ cells correlated with lower CD4+ counts. A higher expression of CD95 in CD4+ and CD8+ lymphocytes correlated with a lower percentage of naive events. Our results might suggest a shift to antigen-activated T cells, expressing molecules increasing their propensity to apoptosis and exhaustion during COVID-19 infection.",
keywords = "Adult, Aged, Aged, 80 and over, Aging, Apoptosis, CD4-Positive T-Lymphocytes, CD8-Positive T-Lymphocytes, CD95 (Fas), COVID-19, Female, Humans, Lymphocyte Count, Lymphocyte Subsets, Lymphopenia, Male, Middle Aged, PD-1, Prognosis, Programmed Cell Death 1 Receptor, SARS-CoV-2, apoptosis, exhaustion, fas Receptor, Adult, Aged, Aged, 80 and over, Aging, Apoptosis, CD4-Positive T-Lymphocytes, CD8-Positive T-Lymphocytes, CD95 (Fas), COVID-19, Female, Humans, Lymphocyte Count, Lymphocyte Subsets, Lymphopenia, Male, Middle Aged, PD-1, Prognosis, Programmed Cell Death 1 Receptor, SARS-CoV-2, apoptosis, exhaustion, fas Receptor",
author = "Silvia Bellesi and Elisabetta Metafuni and Stefan Hohaus and Elena Maiolo and Federica Marchionni and Simone D{\textquoteright}Innocenzo and {La Sorda}, Marilena and Manuela Ferraironi and Francesco Ramundo and Massimo Fantoni and Rita Murri and Antonella Cingolani and Simona Sica and Antonio Gasbarrini and Maurizio Sanguinetti and Patrizia Chiusolo and {De Stefano}, Valerio",
year = "2020",
doi = "10.1111/bjh.17034",
language = "English",
volume = "191",
pages = "207--211",
journal = "British Journal of Haematology",
issn = "0007-1048",
publisher = "Blackwell Science Limited:PO Box 88, Oxford OX2 0NE United Kingdom:011 44 1865 776868, 011 44 1865 206038, EMAIL: journals.cs@blacksci.co.uk, INTERNET: http://www.blackwell-science.com, Fax: 011 44 1865 721205",
}