Incidence and outcome of invasive candidiasis in intensive care units (icus) in europe: Results of the eucandicu project

M. Bassetti*, D. R. Giacobbe, A. Vena, C. Trucchi, F. Ansaldi, Massimo Antonelli, V. Adamkova, C. Alicino, Almyroudi M. -P., E. Atchade, A. M. Azzini, N. Carannante, A. Carnelutti, S. Corcione, A. Cortegiani, G. Dimopoulos, S. Dubler, J. L. Garcia-Garmendia, M. Girardis, O. A. CornelyS. Ianniruberto, B. J. Kullberg, K. Lagrou, Bihan C. Le, R. Luzzati, M. L. N. G. Malbrain, M. Merelli, A. J. Marques, I. Martin-Loeches, A. Mesini, Paiva J. -A., M. Peghin, S. M. Raineri, R. Rautemaa-Richardson, J. Schouten, P. Brugnaro, H. Spapen, P. Tasioudis, Timsit J. -F., V. Tisa, M. Tumbarello, Den Berg C. H. S. B. Van, B. Veber, M. Venditti, G. Voiriot, J. Wauters, P. Montravers

*Autore corrispondente per questo lavoro

Risultato della ricerca: Contributo in rivistaArticolo

40 Citazioni (SciVal)

Abstract

Background: The objective of this study was to assess the cumulative incidence of invasive candidiasis (IC) in intensive care units (ICUs) in Europe. Methods: A multinational, multicenter, retrospective study was conducted in 23 ICUs in 9 European countries, representing the first phase of the candidemia/intra-abdominal candidiasis in European ICU project (EUCANDICU). Results: During the study period, 570 episodes of ICU-acquired IC were observed, with a cumulative incidence of 7.07 episodes per 1000 ICU admissions, with important between-center variability. Separated, non-mutually exclusive cumulative incidences of candidemia and IAC were 5.52 and 1.84 episodes per 1000 ICU admissions, respectively. Crude 30-day mortality was 42%. Age (odds ratio [OR] 1.04 per year, 95% CI 1.02-1.06, p < 0.001), severe hepatic failure (OR 3.25, 95% 1.31-8.08, p 0.011), SOFA score at the onset of IC (OR 1.11 per point, 95% CI 1.04-1.17, p 0.001), and septic shock (OR 2.12, 95% CI 1.24-3.63, p 0.006) were associated with increased 30-day mortality in a secondary, exploratory analysis. Conclusions: The cumulative incidence of IC in 23 European ICUs was 7.07 episodes per 1000 ICU admissions. Future in-depth analyses will allow explaining part of the observed between-center variability, with the ultimate aim of helping to improve local infection control and antifungal stewardship projects and interventions.
Lingua originaleInglese
pagine (da-a)219-219
Numero di pagine1
RivistaCritical Care
Volume23
Numero di pubblicazione1
DOI
Stato di pubblicazionePubblicato - 2019

All Science Journal Classification (ASJC) codes

  • Terapia Intensiva e Rianimazione

Keywords

  • Abdominal candidiasis
  • Aged
  • Candida
  • Candidemia
  • Candidiasis
  • Cross Infection
  • Europe
  • Female
  • Health Care
  • Humans
  • ICU
  • Incidence
  • Intensive Care Units
  • Invasive
  • Male
  • Middle Aged
  • Outcome Assessment
  • Retrospective Studies
  • Risk Factors

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