In vivo thromboxane-dependent platelet activation is persistently enhanced in subjects with impaired glucose tolerance

Giovanna Petrucci, Dario Pitocco, Alfredo Pontecorvi, Bianca Rocca, Alessandro Rizzi, Francesca De Leva, Carlo Patrono, Francesca Santilli, Rossella Liani, Paola Simeone, Romina Tripaldi, Gloria Formoso, Ermanno Angelucci, Maria Golato, Ester Vitacolonna, Agostino Consoli

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

5 Citazioni (Scopus)

Abstract

Background: Impaired glucose tolerance (IGT) is associated with increased cardiovascular morbidity and mortality. Enhanced thromboxane (TX)-dependent platelet activation plays a pivotal role in atherothrombosis and characterizes type 2 diabetes mellitus (DM). Whether this also pertains to IGT is currently unknown. We investigated whether TXA2-dependent platelet activation, as reflected by 11-dehydro-TXB2 (TXM) urinary excretion, is comparably abnormal in IGT as in DM, is persistent over long-term follow-up, changes as a function of metabolic disease progression, and is influenced by food intake. Methods: We prospectively investigated subjects with IGT (n = 48) and two control groups with DM diagnosed either less than 12 months (n = 60) or 12 months or more (n = 58). Results: Baseline TXM excretion was comparable between subjects with IGT and DM, with no evidence of a circadian variation. During a 36-month follow-up, urinary TXM excretion was stable over time in the DM groups, while tended to increase in subjects with IGT. Increasing urinary TXM excretion over time was observed in the subjects who progressed to diabetes vs nonprogressors. Conclusions: We conclude that TXA2-dependent platelet activation was at least as high in IGT as in patients with DM and further increased over time, especially in those who progressed to overt diabetes.
Lingua originaleEnglish
pagine (da-a)e3232-N/A
RivistaDiabetes/Metabolism Research and Reviews
Volume36
DOI
Stato di pubblicazionePubblicato - 2020

Keywords

  • cardiovascular morbidity
  • impaired glucose tolerance
  • platelet activation
  • thromboxane
  • type 2 diabetes mellitus

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