In Vivo Emergence of Tigecycline Resistance in Multidrug-Resistant Klebsiella pneumoniae and Escherichia coli

Teresa Spanu; Giulia De Angelis; Maria Celeste Cipriani; Barbara Pedruzzi; Tiziana D'Inzeo; Maria Cataldo; Gabriele Sganga; Evelina Tacconelli

doi:10.1128/AAC.00234-12

In Vivo Emergence of Tigecycline Resistance in Multidrug-Resistant Klebsiella pneumoniae and Escherichia coli

Teresa Spanu
, Giulia De Angelis
, Maria Celeste Cipriani
, Barbara Pedruzzi
, Tiziana D'Inzeo
, Maria Cataldo
, Gabriele Sganga
, Evelina Tacconelli^*

^*Autore corrispondente per questo lavoro

Risultato della ricerca: Contributo in rivista › Articolo

Abstract

Although resistance to tigecycline has been reported in surveillance studies, a very few reports described the emergence of resistance in vivo. We report two cases of patients with infections due to SHV-12 producing Klebsiella pneumoniae and K. pneumoniae carbapenemase-3 (KPC-3) producing Escherichia coli, which developed tigecycline resistance in vivo after treatment. The reported limited experience underlines the risk of occurrence of tigecycline MIC increase under treatment pressure.

Lingua originale	Inglese
pagine (da-a)	4516-4518
Numero di pagine	3
Rivista	Antimicrobial Agents and Chemotherapy
Volume	2012
Numero di pubblicazione	Agosto
DOI	https://doi.org/10.1128/AAC.00234-12
Stato di pubblicazione	Pubblicato - 2012

All Science Journal Classification (ASJC) codes

Farmacologia
Farmacologia (medica)
Malattie Infettive

Keywords

resistance
tigecycline

Accesso al documento

10.1128/AAC.00234-12

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title = "In Vivo Emergence of Tigecycline Resistance in Multidrug-Resistant Klebsiella pneumoniae and Escherichia coli",

abstract = "Although resistance to tigecycline has been reported in surveillance studies, a very few reports described the emergence of resistance in vivo. We report two cases of patients with infections due to SHV-12 producing Klebsiella pneumoniae and K. pneumoniae carbapenemase-3 (KPC-3) producing Escherichia coli, which developed tigecycline resistance in vivo after treatment. The reported limited experience underlines the risk of occurrence of tigecycline MIC increase under treatment pressure.",

keywords = "resistance, tigecycline, resistance, tigecycline",

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T1 - In Vivo Emergence of Tigecycline Resistance in Multidrug-Resistant Klebsiella pneumoniae and Escherichia coli

AU - Spanu, Teresa

AU - De Angelis, Giulia

AU - Cipriani, Maria Celeste

AU - Pedruzzi, Barbara

AU - D'Inzeo, Tiziana

AU - Cataldo, Maria

AU - Sganga, Gabriele

AU - Tacconelli, Evelina

PY - 2012

Y1 - 2012

N2 - Although resistance to tigecycline has been reported in surveillance studies, a very few reports described the emergence of resistance in vivo. We report two cases of patients with infections due to SHV-12 producing Klebsiella pneumoniae and K. pneumoniae carbapenemase-3 (KPC-3) producing Escherichia coli, which developed tigecycline resistance in vivo after treatment. The reported limited experience underlines the risk of occurrence of tigecycline MIC increase under treatment pressure.

AB - Although resistance to tigecycline has been reported in surveillance studies, a very few reports described the emergence of resistance in vivo. We report two cases of patients with infections due to SHV-12 producing Klebsiella pneumoniae and K. pneumoniae carbapenemase-3 (KPC-3) producing Escherichia coli, which developed tigecycline resistance in vivo after treatment. The reported limited experience underlines the risk of occurrence of tigecycline MIC increase under treatment pressure.

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KW - tigecycline

KW - resistance

KW - tigecycline

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JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

IS - Agosto

ER -

In Vivo Emergence of Tigecycline Resistance in Multidrug-Resistant Klebsiella pneumoniae and Escherichia coli

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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