In Vivo Emergence of Tigecycline Resistance in Multidrug-Resistant Klebsiella pneumoniae and Escherichia coli

Teresa Spanu, Giulia De Angelis, Tiziana D'Inzeo, Gabriele Sganga, Maria Celeste Cipriani, Barbara Pedruzzi, Maria Cataldo, Evelina Tacconelli

Risultato della ricerca: Contributo in rivistaArticolo in rivista

Abstract

Although resistance to tigecycline has been reported in surveillance studies, a very few reports described the emergence of resistance in vivo. We report two cases of patients with infections due to SHV-12 producing Klebsiella pneumoniae and K. pneumoniae carbapenemase-3 (KPC-3) producing Escherichia coli, which developed tigecycline resistance in vivo after treatment. The reported limited experience underlines the risk of occurrence of tigecycline MIC increase under treatment pressure.
Lingua originaleEnglish
pagine (da-a)4516-4518
Numero di pagine3
RivistaAntimicrobial Agents and Chemotherapy
Volume2012
DOI
Stato di pubblicazionePubblicato - 2012

Keywords

  • resistance
  • tigecycline

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