In Vivo Emergence of Tigecycline Resistance in Multidrug-Resistant Klebsiella pneumoniae and Escherichia coli

Teresa Spanu; Giulia De Angelis; Maria Celeste Cipriani; Barbara Pedruzzi; Tiziana D'Inzeo; Maria Cataldo; Gabriele Sganga; Evelina Tacconelli

doi:10.1128/AAC.00234-12

In Vivo Emergence of Tigecycline Resistance in Multidrug-Resistant Klebsiella pneumoniae and Escherichia coli

Teresa Spanu, Giulia De Angelis, Maria Celeste Cipriani, Barbara Pedruzzi, Tiziana D'Inzeo, Maria Cataldo, Gabriele Sganga, Evelina Tacconelli

Risultato della ricerca: Contributo in rivista › Articolo in rivista

Abstract

Although resistance to tigecycline has been reported in surveillance studies, a very few reports described the emergence of resistance in vivo. We report two cases of patients with infections due to SHV-12 producing Klebsiella pneumoniae and K. pneumoniae carbapenemase-3 (KPC-3) producing Escherichia coli, which developed tigecycline resistance in vivo after treatment. The reported limited experience underlines the risk of occurrence of tigecycline MIC increase under treatment pressure.

Lingua originale	English
pagine (da-a)	4516-4518
Numero di pagine	3
Rivista	Antimicrobial Agents and Chemotherapy
Volume	2012
DOI	https://doi.org/10.1128/AAC.00234-12
Stato di pubblicazione	Pubblicato - 2012

Keywords

resistance
tigecycline

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10.1128/AAC.00234-12

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title = "In Vivo Emergence of Tigecycline Resistance in Multidrug-Resistant Klebsiella pneumoniae and Escherichia coli",

abstract = "Although resistance to tigecycline has been reported in surveillance studies, a very few reports described the emergence of resistance in vivo. We report two cases of patients with infections due to SHV-12 producing Klebsiella pneumoniae and K. pneumoniae carbapenemase-3 (KPC-3) producing Escherichia coli, which developed tigecycline resistance in vivo after treatment. The reported limited experience underlines the risk of occurrence of tigecycline MIC increase under treatment pressure.",

keywords = "resistance, tigecycline, resistance, tigecycline",

author = "Teresa Spanu and {De Angelis}, Giulia and Cipriani, {Maria Celeste} and Barbara Pedruzzi and Tiziana D'Inzeo and Maria Cataldo and Gabriele Sganga and Evelina Tacconelli",

year = "2012",

doi = "10.1128/AAC.00234-12",

language = "English",

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pages = "4516--4518",

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T1 - In Vivo Emergence of Tigecycline Resistance in Multidrug-Resistant Klebsiella pneumoniae and Escherichia coli

AU - Spanu, Teresa

AU - De Angelis, Giulia

AU - Cipriani, Maria Celeste

AU - Pedruzzi, Barbara

AU - D'Inzeo, Tiziana

AU - Cataldo, Maria

AU - Sganga, Gabriele

AU - Tacconelli, Evelina

PY - 2012

Y1 - 2012

N2 - Although resistance to tigecycline has been reported in surveillance studies, a very few reports described the emergence of resistance in vivo. We report two cases of patients with infections due to SHV-12 producing Klebsiella pneumoniae and K. pneumoniae carbapenemase-3 (KPC-3) producing Escherichia coli, which developed tigecycline resistance in vivo after treatment. The reported limited experience underlines the risk of occurrence of tigecycline MIC increase under treatment pressure.

AB - Although resistance to tigecycline has been reported in surveillance studies, a very few reports described the emergence of resistance in vivo. We report two cases of patients with infections due to SHV-12 producing Klebsiella pneumoniae and K. pneumoniae carbapenemase-3 (KPC-3) producing Escherichia coli, which developed tigecycline resistance in vivo after treatment. The reported limited experience underlines the risk of occurrence of tigecycline MIC increase under treatment pressure.

KW - resistance

KW - tigecycline

KW - resistance

KW - tigecycline

UR - http://hdl.handle.net/10807/24568

U2 - 10.1128/AAC.00234-12

DO - 10.1128/AAC.00234-12

M3 - Article

SN - 0066-4804

VL - 2012

SP - 4516

EP - 4518

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

ER -

In Vivo Emergence of Tigecycline Resistance in Multidrug-Resistant Klebsiella pneumoniae and Escherichia coli

Abstract

Keywords

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