"In vitro" study of liver slices lipid (1-14C) acetate incorporation in experimental diabetes

Av Greco; Geltrude Mingrone; E Peruzzi; Paolo Orlando

doi:10.1016/S0232-1513(81)80003-5

"In vitro" study of liver slices lipid (1-14C) acetate incorporation in experimental diabetes

Av Greco^*
, Geltrude Mingrone
, E Peruzzi
, Paolo Orlando

^*Autore corrispondente per questo lavoro

Risultato della ricerca: Contributo in rivista › Articolo

1 Citazioni (Scopus)

Abstract

The effect of insulin deficiency on lipid synthesis in the liver of normal rats, diabetic rats by alloxan and pancreatectomized rats was studied in vitro using (1-14C) acetate as lipid precursor. Insulin deficiency induces an increased incorporation of (1-14C) acetate into triglycerides in rat liver. This is particularly evident in pancreatectomized rats with respect to alloxan diabetic rats. It is concluded that in experimental diabetes an atherogenous metabolic pattern is elaborated by the liver.

Lingua originale	Inglese
pagine (da-a)	6-10
Numero di pagine	5
Rivista	Experimental Pathology
Volume	20
Numero di pubblicazione	1
DOI	https://doi.org/10.1016/S0232-1513(81)80003-5
Stato di pubblicazione	Pubblicato - 1981

All Science Journal Classification (ASJC) codes

Anatomia Patologica e Medicina Forense

Keywords

Acetates
Animals
Arteries
Arteriosclerosis
Carbon Radioisotopes
Diabetes Mellitus
Experimental
Inbred Strains
Lipids
Liver
Male
Rats

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10.1016/S0232-1513(81)80003-5

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abstract = "The effect of insulin deficiency on lipid synthesis in the liver of normal rats, diabetic rats by alloxan and pancreatectomized rats was studied in vitro using (1-14C) acetate as lipid precursor. Insulin deficiency induces an increased incorporation of (1-14C) acetate into triglycerides in rat liver. This is particularly evident in pancreatectomized rats with respect to alloxan diabetic rats. It is concluded that in experimental diabetes an atherogenous metabolic pattern is elaborated by the liver.",

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author = "Av Greco and Geltrude Mingrone and E Peruzzi and Paolo Orlando",

year = "1981",

doi = "10.1016/S0232-1513(81)80003-5",

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AU - Greco, Av

AU - Mingrone, Geltrude

AU - Peruzzi, E

AU - Orlando, Paolo

PY - 1981

Y1 - 1981

N2 - The effect of insulin deficiency on lipid synthesis in the liver of normal rats, diabetic rats by alloxan and pancreatectomized rats was studied in vitro using (1-14C) acetate as lipid precursor. Insulin deficiency induces an increased incorporation of (1-14C) acetate into triglycerides in rat liver. This is particularly evident in pancreatectomized rats with respect to alloxan diabetic rats. It is concluded that in experimental diabetes an atherogenous metabolic pattern is elaborated by the liver.

AB - The effect of insulin deficiency on lipid synthesis in the liver of normal rats, diabetic rats by alloxan and pancreatectomized rats was studied in vitro using (1-14C) acetate as lipid precursor. Insulin deficiency induces an increased incorporation of (1-14C) acetate into triglycerides in rat liver. This is particularly evident in pancreatectomized rats with respect to alloxan diabetic rats. It is concluded that in experimental diabetes an atherogenous metabolic pattern is elaborated by the liver.

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KW - Liver

KW - Male

KW - Rats

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KW - Arteries

KW - Arteriosclerosis

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KW - Diabetes Mellitus

KW - Experimental

KW - Inbred Strains

KW - Lipids

KW - Liver

KW - Male

KW - Rats

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"In vitro" study of liver slices lipid (1-14C) acetate incorporation in experimental diabetes

Abstract

All Science Journal Classification (ASJC) codes

Keywords

OSS delle Nazioni Unite

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