"In vitro" study of liver slices lipid (1-14C) acetate incorporation in experimental diabetes

Geltrude Mingrone, Paolo Orlando

Risultato della ricerca: Contributo in rivistaArticolo in rivista

1 Citazioni (Scopus)

Abstract

The effect of insulin deficiency on lipid synthesis in the liver of normal rats, diabetic rats by alloxan and pancreatectomized rats was studied in vitro using (1-14C) acetate as lipid precursor. Insulin deficiency induces an increased incorporation of (1-14C) acetate into triglycerides in rat liver. This is particularly evident in pancreatectomized rats with respect to alloxan diabetic rats. It is concluded that in experimental diabetes an atherogenous metabolic pattern is elaborated by the liver.
Lingua originaleEnglish
pagine (da-a)6-10
Numero di pagine5
RivistaExperimental Pathology
Volume20
Stato di pubblicazionePubblicato - 1981

Keywords

  • Acetates
  • Animals
  • Arteries
  • Arteriosclerosis
  • Carbon Radioisotopes
  • Diabetes Mellitus, Experimental
  • Lipids
  • Liver
  • Male
  • Rats
  • Rats, Inbred Strains

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